#Fumarate update

#FumarateHydratase inhibitor FHIN1 or induced KO in Macrophage ⏫chronic inflammation (LPS or SLE)-induced Interferon signal

⏫#MitochondrialMembranePotential➡️
⏫mtRNA➡️
TLR7 or RIG-I-MDA5 RNA sensors➡️
⏫IFNβ

Work in #Atherosclerosis?😁

@nature.com 2023
www.nature.com/articles/s41...

#Fumarate update

Fumarate induces vesicular release of mtDNA to drive innate immunity

Global Fh1 #FumarateHydratase KO in adult🐭for 10 d➡️
⏫Kidney Fumarate, Inflammation w/o Immune cell infiltr

⏫cyto-mtDNA
➡️cGAS-STING
RIG-I too?🥸

@frezzalab.bsky.social #Nature 2023
www.nature.com/articles/s41...