Drs Franco Vairoletti, Cecilia Saiz & Gustavo Salinas discuss pharmacological targeting of the #helminth #complexII: are there any #rhodoquinone-driven adaptations? #Benzamide #Succinate #Dehydrogenase #Fumarate #Reductase #Hypoxia @ipmontevideo.bsky.social
authors.elsevier.com/a/1lRcz5Eb1x...
#Fumarate update
Functional implications of fumarate-induced cysteine succination
Does Fumarase/FH1 deficiency (via either mitochondrial dysfunction, redox imbalance, or protein succination/inactivation) predispose #AorticAneurysm?🧐
#TrendsBiochem 2025
linkinghub.elsevier.com/retrieve/pii...
#Fumarate update
Gang of 3: How the Krebs cycle-linked metabolites itaconate, succinate, and fumarate regulate macrophages & inflammation
Dual role in Inflammation
Anti-
KEAP1-NRF2
GSDMD
NLRP3
IL-10
Pro-
mtDNA mtRNA➡️IFNβ
#CellMetab 2025
www.sciencedirect.com/science/arti...
#Fumarate update
#FumarateHydratase inhibitor FHIN1 or induced KO in Macrophage ⏫chronic inflammation (LPS or SLE)-induced Interferon signal
⏫#MitochondrialMembranePotential➡️
⏫mtRNA➡️
TLR7 or RIG-I-MDA5 RNA sensors➡️
⏫IFNβ
Work in #Atherosclerosis?😁
@nature.com 2023
www.nature.com/articles/s41...
#Fumarate update
Oncometabolites (2-hydroxyglutarate, fumarate, succinate, mutations of IDH1/2, FH, SDHA/B/C/D)⏬ #HomologyDependentRepair #DNARepair & sensitize tumor cell to PARPi
Oncometabolites▶️
⏬ KDM4B▶️
Persistent H3K9me3 at DNA breaks▶️
⏬DNA repair
#Nature 2020
www.nature.com/articles/s41...
#Fumarate update
Fumarate induces vesicular release of mtDNA to drive innate immunity
Global Fh1 #FumarateHydratase KO in adult🐭for 10 d➡️
⏫Kidney Fumarate, Inflammation w/o Immune cell infiltr
⏫cyto-mtDNA
➡️cGAS-STING
RIG-I too?🥸
@frezzalab.bsky.social #Nature 2023
www.nature.com/articles/s41...
Speaker Highlight - Luke O'Neill
Delighted that @lukeanthonyoneill.bsky.social from @tcddublin.bsky.social will join us at www.emds2025.com. Looking forward to the #macrophage #metabolism masterclass already! #itaconate #fumarate & much more!
@britsocimm.bsky.social [Background photo:Chris Close]
SciTech Chronicles. . . . . . . . .Feb 4th, 2025
bit.ly/stc020425
#Graphene #Tattoos #Biosensors #epidermal #Boreal #MODIS #Migration #Tundra #exudates #methanogens #SUSIBA2 #fumarate #ethanol #Fibre-optic #DAS #axis #algorithm #Honeybee #Varroa #timeframe #adherence #treatment
High-yield #rice breed emits up to 70% less #methane
#methanogens #soil #microbiome #fumarate #ethanol #root #exudates
phys.org/news/2025-02...
Metabolite #fumarate can reveal #CellDamage: New method to generate fumarate for #MRI presented www.uni-mainz.de/presse/aktuell/13510_ENG... #metabolism #biosensor @ZULFNMR @PNASNews
