FGF13 Metabolism

Adipocyte or BAT FGF13 KO in adult🐭
👉Improved glucose metabolism
👉⏬Liver Steatosis
👉⏫BAT UCP1 & Thermogenesis & Energy expenditure
👉⏬Adipocyte Inflamm
👉⏫Adipocyte Mitochondria density/size OXPHOS
👉⏫Adipocyte Caveolae

#CellMetab 2025
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SenCID

a 6-module single-cell transcript feature for #Senescence
CROP-seq

Smooth muscle cell ➡️SID2
Endothelial cell ➡️SID4
Fibroblast ➡️SID5

Capture 👤Lung aging (AT2), Skin aging (fibroblast), Osteoarthritis (chondrocyte), Atherosclerosis (aortic EC)

#CellMetab 2024
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A metabolic atlas of mouse aging Humans are living longer and experiencing more age-related diseases, many of which involve metabolic dysregulation, but how metabolism changes in mult…

A metabolic atlas of mouse aging #CellMetab #MassSpec www.sciencedirect.com/science/arti...

#Fumarate update

Gang of 3: How the Krebs cycle-linked metabolites itaconate, succinate, and fumarate regulate macrophages & inflammation

Dual role in Inflammation

Anti-
KEAP1-NRF2
GSDMD
NLRP3
IL-10

Pro-
mtDNA mtRNA➡️IFNβ

#CellMetab 2025
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Circulating glycerate predicts resilience to fructose-induced hepatic steatosis Excessive intake of dietary fructose increases the risk of metabolic-dysfunction-associated steatotic liver disease (MASLD), cirrhosis, and cancers. H…

Circulating glycerate predicts resilience to fructose-induced hepatic steatosis #CellMetab #MasssSpec www.sciencedirect.com/science/arti...

#Diabetes #CellMetab #Medsky

Always have a plan B🤠

Two Parallel Cascades of Adipocytic Thermogenesis in adult🐭
UCP1+Creatine Kinase B

Unlike germline Ucp1 KO, adult #BrownAdiposeTissue Ucp1 KO▶️No defects in Adipocytic Thermogenesis

Adipocyte UCP1/CKB dKO▶️80% Hypothermia

#CellMetab 2024
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