Excited to present our work at #SFEBES2026 on how miR-10b-5p influences adipocyte #differentiation and #thermogenic programming in #WhiteAdipose tissue 🔥
We uncover a novel miR-10b–Tub regulatory axis shaping #BrownAdiposeTissue physiology.
#Metabolism #Thermogenesis #miRNA @ntumeta.bsky.social
Left: Schematic showing how brown fat reprograms its lipid landscape during fasting-refeeding cycles—glucose, and saturated fatty acids converge to power heat generation and storage. Credit: Meilian Liu. Right: The representative images of H&E staining for BAT, liver, gWAT and iWAT.
Brown #adipose tissue is energetically important and has been linked to #MetabolicHealth. This study provides a detailed view of #lipid metabolism in #BrownAdiposeTissue, showing how lipid dynamics are remodeled during periods of fasting & refeeding @plosbiology.org 🧪 plos.io/49v1hI8
Left: Schematic showing how brown fat reprograms its lipid landscape during fasting-refeeding cycles—glucose, and saturated fatty acids converge to power heat generation and storage. Credit: Meilian Liu. Right: The representative images of H&E staining for BAT, liver, gWAT and iWAT.
Brown #adipose tissue is energetically important and has been linked to #MetabolicHealth. This study provides a detailed view of #lipid metabolism in #BrownAdiposeTissue, showing how lipid dynamics are remodeled during periods of fasting & refeeding @plosbiology.org 🧪 plos.io/49v1hI8
Left: Schematic showing how brown fat reprograms its lipid landscape during fasting-refeeding cycles—glucose, and saturated fatty acids converge to power heat generation and storage. Credit: Meilian Liu. Right: The representative images of H&E staining for BAT, liver, gWAT and iWAT.
Brown #adipose tissue is energetically important and has been linked to #MetabolicHealth. This study provides a detailed view of #lipid metabolism in #BrownAdiposeTissue, showing how lipid dynamics are remodeled during periods of fasting & refeeding @plosbiology.org 🧪 plos.io/49v1hI8
Top left: Structural prediction of the human ADRB3-S100B complex using AlphaFold2/ColabFold. The human ADRB3/S100B complex model (left) was predicted by ColabFold and colored in blue, cyan, yellow, and orange according to different prediction confidence (pLDDT, predicted local distance difference test). Surface electrostatic representation showing ADRB3 (deep teal) and S100B (orange) with positive and negative charges indicated in blue and red, respectively (right). Top right: Schematic model illustrating the proposed ADRB3-S100B signaling axis. SCN lesioning enhances SNS activity, thereby promoting ADRB3 signaling and upregulating S100B expression. S100B, in turn, increases ADRB3 sensitivity, establishing a positive feedback loop that sustains thermogenesis and stimulates preadipocyte proliferation. Created in BioRender.com. Bottom: Working model illustrating the SCN-ADRB3-S100B axis in BAT during TRF conducted at ZT16-ZT20 in a subthermoneutral environment, the SCN regulates BAT thermogenic plasticity via SNS output. SCN lesioning enhances ADRB3 signaling and S100B expression, which together form a positive feedback loop that amplifies β3-adrenergic sensitivity, promotes preadipocyte proliferation, suppresses senescence, and sustains glucose-driven thermogenesis.
#BrownAdiposeTissue (BAT) plays a role in #thermogenesis & energy homeostasis. This study shows how signals from the #SuprachiasmaticNucleus coordinate metabolic flexibility of BAT, via an ADRB3-S100B signaling axis, with therapeutic implications @plosbiology.org 🧪 plos.io/3MHc3Df
Top left: Structural prediction of the human ADRB3-S100B complex using AlphaFold2/ColabFold. The human ADRB3/S100B complex model (left) was predicted by ColabFold and colored in blue, cyan, yellow, and orange according to different prediction confidence (pLDDT, predicted local distance difference test). Surface electrostatic representation showing ADRB3 (deep teal) and S100B (orange) with positive and negative charges indicated in blue and red, respectively (right). Top right: Schematic model illustrating the proposed ADRB3-S100B signaling axis. SCN lesioning enhances SNS activity, thereby promoting ADRB3 signaling and upregulating S100B expression. S100B, in turn, increases ADRB3 sensitivity, establishing a positive feedback loop that sustains thermogenesis and stimulates preadipocyte proliferation. Created in BioRender.com. Bottom: Working model illustrating the SCN-ADRB3-S100B axis in BAT during TRF conducted at ZT16-ZT20 in a subthermoneutral environment, the SCN regulates BAT thermogenic plasticity via SNS output. SCN lesioning enhances ADRB3 signaling and S100B expression, which together form a positive feedback loop that amplifies β3-adrenergic sensitivity, promotes preadipocyte proliferation, suppresses senescence, and sustains glucose-driven thermogenesis.
#BrownAdiposeTissue (BAT) plays a role in #thermogenesis & energy homeostasis. This study shows how signals from the #SuprachiasmaticNucleus coordinate metabolic flexibility of BAT, via an ADRB3-S100B signaling axis, with therapeutic implications @plosbiology.org 🧪 plos.io/3MHc3Df
Top left: Structural prediction of the human ADRB3-S100B complex using AlphaFold2/ColabFold. The human ADRB3/S100B complex model (left) was predicted by ColabFold and colored in blue, cyan, yellow, and orange according to different prediction confidence (pLDDT, predicted local distance difference test). Surface electrostatic representation showing ADRB3 (deep teal) and S100B (orange) with positive and negative charges indicated in blue and red, respectively (right). Top right: Schematic model illustrating the proposed ADRB3-S100B signaling axis. SCN lesioning enhances SNS activity, thereby promoting ADRB3 signaling and upregulating S100B expression. S100B, in turn, increases ADRB3 sensitivity, establishing a positive feedback loop that sustains thermogenesis and stimulates preadipocyte proliferation. Created in BioRender.com. Bottom: Working model illustrating the SCN-ADRB3-S100B axis in BAT during TRF conducted at ZT16-ZT20 in a subthermoneutral environment, the SCN regulates BAT thermogenic plasticity via SNS output. SCN lesioning enhances ADRB3 signaling and S100B expression, which together form a positive feedback loop that amplifies β3-adrenergic sensitivity, promotes preadipocyte proliferation, suppresses senescence, and sustains glucose-driven thermogenesis.
#BrownAdiposeTissue (BAT) plays a role in #thermogenesis & energy homeostasis. This study shows how signals from the #SuprachiasmaticNucleus coordinate metabolic flexibility of BAT, via an ADRB3-S100B signaling axis, with therapeutic implications @plosbiology.org 🧪 plos.io/3MHc3Df
Synapse: Your Connection to our MSK Authors
Meet: Heiko Schoder
Research Focus: Radiology; Chief Attending
Brown adipose tissue machine learning nnU-Net V2 network using TriDFusion (3DF)
synapse.mskcc.org/synapse/work...
#BrownAdiposeTissue #BrownFat #nnUNet #nnUNetV2 #TriDFusion #3DF
Review From William T. Festuccia, #mTORC1 and 2 Adrenergic Regulation and Function in Brown Adipose Tissue, doi.org/10.1152/phys...
#BrownAdiposeTissue
Always have a plan B🤠
Two Parallel Cascades of Adipocytic Thermogenesis in adult🐭
UCP1+Creatine Kinase B
Unlike germline Ucp1 KO, adult #BrownAdiposeTissue Ucp1 KO▶️No defects in Adipocytic Thermogenesis
Adipocyte UCP1/CKB dKO▶️80% Hypothermia
#CellMetab 2024
www.sciencedirect.com/science/arti...
