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SLIT3 fragments orchestrate neurovascular expansion and thermogenesis in brown adipose tissue - Nature Communications Brown adipocytes are embedded within an intricate network of blood vessels and sympathetic nerves that support their development and thermogenic function. This study shows that adipocyte progenitor ce...

Don't miss the new @NatureComms paper, "#SLIT3 fragments orchestrate #neurovascular expansion and #thermogenesis in brown adipose tissue," by our departmental colleague Dr. Matthew Greenblatt!
www.nature.com/articles/s41...

❄️ MYTH BUSTER: "Cold water burns more calories"
TRUTH: Warming cold water burns ~8 calories per glass. You'd need to drink 50+ glasses for 1 cookie's worth! Thermogenesis is real but trivial. Focus on big rocks, not pebbles 🪨 #MacroMate #Thermogenesis

Jacob With Christensen, David Tandio, Matthias Anagho-Mattanovich & Jens Lund from @ucph.bsky.social examine the work of Montané et al. into tracing #lactate and its functions in adipose #thermogenesis ✍️

🔗 Read the #JournalClub article here 👇️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

Excited to present our work at #SFEBES2026 on how miR-10b-5p influences adipocyte #differentiation and #thermogenic programming in #WhiteAdipose tissue 🔥
We uncover a novel miR-10b–Tub regulatory axis shaping #BrownAdiposeTissue physiology.
#Metabolism #Thermogenesis #miRNA @ntumeta.bsky.social

Synapse: Your Connection to our MSK Authors
Meet: Tobias Christian Walther
Research Focus: Cell Biology; Non-Stipend Program Chair

DGAT-driven futile lipid cycling has a pronounced, yet concealed, thermogenic function

synapse.mskcc.org/synapse/work...
#DGAT #LipidMetabolism #Thermogenesis

Metabolism slowdown? CitrusBurn revives it without stimulants!
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🤢 #CitrusBurn #MetabolismSupport #Over35WeightLoss #NaturalFatBurn #HealthyAging #SlimAfter35 #WeightLossHelp #Thermogenesis #Wellness #GetLean

❄️ MYTH BUSTER: "Cold water burns more calories"
TRUTH: Warming cold water burns ~8 calories per glass. You'd need to drink 50+ glasses for 1 cookie's worth! Thermogenesis is real but trivial. Focus on big rocks, not pebbles 🪨 #MacroMate #Thermogenesis

❄️ MYTH BUSTER: "Cold water burns more calories"
TRUTH: Warming cold water burns ~8 calories per glass. You'd need to drink 50+ glasses for 1 cookie's worth! Thermogenesis is real but trivial. Focus on big rocks, not pebbles 🪨 #MacroMate #Thermogenesis

Geo-Engines delivers modular 8MW units of clean, baseload energy - no emissions, no pollution. Scale to 40MW, 80MW, 240MW and beyond. Powered by geology, not guesswork. #CleanEnergy #GeoEngines #Thermogenesis

Protocol for targeted gene manipulation and thermogenic evaluation in mouse brown adipocytes Adeno-associated viruses (AAVs) are versatile, non-integrating vectors for in vivo gene delivery. We present a reproducible workflow for generating Cr…

In @cp-starprotocols.bsky.social we present a protocol for generating and targeting Cre-dependent FLEX-AAVs in vivo, for the assessment of #thermogenesis in brown #adipocytes using #respirometry.
@mcgillgci.bsky.social

Link here👇
www.sciencedirect.com/science/arti...

❄️ MYTH BUSTER: "Cold water burns more calories"
TRUTH: Warming cold water burns ~8 calories per glass. You'd need to drink 50+ glasses for 1 cookie's worth! Thermogenesis is real but trivial. Focus on big rocks, not pebbles 🪨 #MacroMate #Thermogenesis

Top left: Structural prediction of the human ADRB3-S100B complex using AlphaFold2/ColabFold. The human ADRB3/S100B complex model (left) was predicted by ColabFold and colored in blue, cyan, yellow, and orange according to different prediction confidence (pLDDT, predicted local distance difference test). Surface electrostatic representation showing ADRB3 (deep teal) and S100B (orange) with positive and negative charges indicated in blue and red, respectively (right). Top right: Schematic model illustrating the proposed ADRB3-S100B signaling axis. SCN lesioning enhances SNS activity, thereby promoting ADRB3 signaling and upregulating S100B expression. S100B, in turn, increases ADRB3 sensitivity, establishing a positive feedback loop that sustains thermogenesis and stimulates preadipocyte proliferation. Created in BioRender.com. Bottom: Working model illustrating the SCN-ADRB3-S100B axis in BAT during TRF conducted at ZT16-ZT20 in a subthermoneutral environment, the SCN regulates BAT thermogenic plasticity via SNS output. SCN lesioning enhances ADRB3 signaling and S100B expression, which together form a positive feedback loop that amplifies β3-adrenergic sensitivity, promotes preadipocyte proliferation, suppresses senescence, and sustains glucose-driven thermogenesis.

#BrownAdiposeTissue (BAT) plays a role in #thermogenesis & energy homeostasis. This study shows how signals from the #SuprachiasmaticNucleus coordinate metabolic flexibility of BAT, via an ADRB3-S100B signaling axis, with therapeutic implications @plosbiology.org 🧪 plos.io/3MHc3Df

Top left: Structural prediction of the human ADRB3-S100B complex using AlphaFold2/ColabFold. The human ADRB3/S100B complex model (left) was predicted by ColabFold and colored in blue, cyan, yellow, and orange according to different prediction confidence (pLDDT, predicted local distance difference test). Surface electrostatic representation showing ADRB3 (deep teal) and S100B (orange) with positive and negative charges indicated in blue and red, respectively (right). Top right: Schematic model illustrating the proposed ADRB3-S100B signaling axis. SCN lesioning enhances SNS activity, thereby promoting ADRB3 signaling and upregulating S100B expression. S100B, in turn, increases ADRB3 sensitivity, establishing a positive feedback loop that sustains thermogenesis and stimulates preadipocyte proliferation. Created in BioRender.com. Bottom: Working model illustrating the SCN-ADRB3-S100B axis in BAT during TRF conducted at ZT16-ZT20 in a subthermoneutral environment, the SCN regulates BAT thermogenic plasticity via SNS output. SCN lesioning enhances ADRB3 signaling and S100B expression, which together form a positive feedback loop that amplifies β3-adrenergic sensitivity, promotes preadipocyte proliferation, suppresses senescence, and sustains glucose-driven thermogenesis.

#BrownAdiposeTissue (BAT) plays a role in #thermogenesis & energy homeostasis. This study shows how signals from the #SuprachiasmaticNucleus coordinate metabolic flexibility of BAT, via an ADRB3-S100B signaling axis, with therapeutic implications @plosbiology.org 🧪 plos.io/3MHc3Df

Top left: Structural prediction of the human ADRB3-S100B complex using AlphaFold2/ColabFold. The human ADRB3/S100B complex model (left) was predicted by ColabFold and colored in blue, cyan, yellow, and orange according to different prediction confidence (pLDDT, predicted local distance difference test). Surface electrostatic representation showing ADRB3 (deep teal) and S100B (orange) with positive and negative charges indicated in blue and red, respectively (right). Top right: Schematic model illustrating the proposed ADRB3-S100B signaling axis. SCN lesioning enhances SNS activity, thereby promoting ADRB3 signaling and upregulating S100B expression. S100B, in turn, increases ADRB3 sensitivity, establishing a positive feedback loop that sustains thermogenesis and stimulates preadipocyte proliferation. Created in BioRender.com. Bottom: Working model illustrating the SCN-ADRB3-S100B axis in BAT during TRF conducted at ZT16-ZT20 in a subthermoneutral environment, the SCN regulates BAT thermogenic plasticity via SNS output. SCN lesioning enhances ADRB3 signaling and S100B expression, which together form a positive feedback loop that amplifies β3-adrenergic sensitivity, promotes preadipocyte proliferation, suppresses senescence, and sustains glucose-driven thermogenesis.

#BrownAdiposeTissue (BAT) plays a role in #thermogenesis & energy homeostasis. This study shows how signals from the #SuprachiasmaticNucleus coordinate metabolic flexibility of BAT, via an ADRB3-S100B signaling axis, with therapeutic implications @plosbiology.org 🧪 plos.io/3MHc3Df

❄️ MYTH BUSTER: "Cold water burns more calories"
TRUTH: Warming cold water burns ~8 calories per glass. You'd need to drink 50+ glasses for 1 cookie's worth! Thermogenesis is real but trivial. Focus on big rocks, not pebbles 🪨 #MacroMate #Thermogenesis

❄️ MYTH BUSTER: "Cold water burns more calories"
TRUTH: Warming cold water burns ~8 calories per glass. You'd need to drink 50+ glasses for 1 cookie's worth! Thermogenesis is real but trivial. Focus on big rocks, not pebbles 🪨 #MacroMate #Thermogenesis

youtu.be/CVhyzEAf740
Greek yogurt's probiotics balance gut health, aiding weight regulation.

🔔 Looking to enhance your wellness journey
www.youtube.com/@WELLNEVERSI...

#WeightLoss #Probiotics #Thermogenesis #BellyFat #MetabolismBoost #Fat #fatburn #WeightLossFoods #Wellneversity #hormonalbalance

❄️ MYTH BUSTER: "Cold water burns more calories"
TRUTH: Warming cold water burns ~8 calories per glass. You'd need to drink 50+ glasses for 1 cookie's worth! Thermogenesis is real but trivial. Focus on big rocks, not pebbles 🪨 #MacroMate #Thermogenesis

✨New issue!✨

Check out the latest in #metabolism research from across all disciplines.

Read about #TumourMetabolism, #Lactate signalling, #WeighLoss, #Thermogenesis, #DietaryInterventions and many more topics!

🧪

www.nature.com/natmetab/vol...

Picture of a naked mole-rat in a fleece bed

🧵1/15 Delighted to share our study on the naked mole-rat (NMR): a mammal with bizarre thermal biology, notorious longevity, and cancer resistance. But how do NMRs maintain (or fail to maintain) their body temperature? Our latest work digs deep! #ThermalBiology #Thermogenesis

Our paper on the effects of #larval #thermogenesis in #labscale trials is officially out in @cp-iscience.bsky.social.
We explored how larval #densities drive thermogenesis, influencing both the #gut and #substrate #microbiota.

🔗 doi.org/10.1016/j.is...

Funded by the @fwf-at.bsky.social

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Haem biosynthesis regulates BCAA catabolism and thermogenesis in brown adipose tissue - Nature Metabolism Inhibition of haem synthesis is shown to lead to the accumulation of branched-chain amino acids in the brown adipose tissue of mice, which reduces UCP1 levels and impairs thermogenesis.

RESEARCH | ‪@dylanduerre.bsky.social @andreagalmozzi.bsky.social‬ et al. - ‪@uwmadison.bsky.social‬

Inhibition of haem synthesis is shown to lead to the accumulation of branched-chain amino acids in the brown adipose tissue of mice, which impairs #thermogenesis 🐁🌡️

www.nature.com/articles/s42...

Meet @jhobbs22.bsky.social, a 1st-year PhD student in the @mark-christian-lab.bsky.social at #SHIMR_NTU. Jacob is investigating mechanisms that regulate #BrownAdipose tissue, aiming to turn up the heat on #BrownAdipocytes and advance our understanding of #thermogenesis and #MetabolicHealth 🧬❄️🔥