#Fumarate update

Oncometabolites (2-hydroxyglutarate, fumarate, succinate, mutations of IDH1/2, FH, SDHA/B/C/D)⏬ #HomologyDependentRepair #DNARepair & sensitize tumor cell to PARPi

Oncometabolites▶️
⏬ KDM4B▶️
Persistent H3K9me3 at DNA breaks▶️
⏬DNA repair

#Nature 2020
www.nature.com/articles/s41...