Heteromerization of G Protein-coupled Estrogen Receptor With the LH Receptor Biases G Protein Signaling Abstract. LH/choriogonadotropin (hCG) receptor (LHCGR) and the G protein-coupled estrogen receptor (GPER) are coexpressed in the ovary and support reproduc

Heteromerization of G Protein-coupled Estrogen Receptor With the LH Receptor Biases G Protein Signaling. Read more in #Endocrinology: bit.ly/49zJVes #GPER #LHCGR #LH #hCG #GqProtein @endocrinesociety.bsky.social

New review explores how #GPER contributes to #Endocrine resistance in HR+ #BreastCancer via genetic, #Epigenetic & microenvironmental changes, and its potential as a future #therapeutic target. @uchicagocancer.bsky.social #medsky‬ ‬‬

#OpenAccess: www.sciencedirect.com/science/arti...

This review from @uchicagocancer.bsky.social summarizes the diverse mechanisms through which #GPER mediates #EndocrineResistance, #epigenetic and non-genetic variations, and highlights it as a potential therapeutic target for overcoming endocrine resistance of HR+ #BreastCancer.

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