RESEARCH PAPER: Mutant p53 binds and controls estrogen receptor activity to drive endocrine resistance in ovarian cancer
By Shao et al., and Maureen Murphy
➡️ https://genesdev.cshlp.org/content/40/3-4/199.full

The Wistar Institute
#ovariancancer #p53 #cancertherapy #endocrineresistance

This review from @uchicagocancer.bsky.social summarizes the diverse mechanisms through which #GPER mediates #EndocrineResistance, #epigenetic and non-genetic variations, and highlights it as a potential therapeutic target for overcoming endocrine resistance of HR+ #BreastCancer.

buff.ly/iG0Tq5G