#GenomeBiologyi2bc

Today was the last scientific council of #GenomeBiologyi2bc. Thank you @betermieri2bc.bsky.social, #Julie_Soutourina and @phbouloc.bsky.social , for your support and for creating such a great scientific environment.

🎉🥳👏Congratulations to Olivier and to the consortium. Excellent results will come to light soon in the #GenomeBiologyI2BC Department.

Another new team at #GenomeBiologyI2BC. Congratulations @cecilecourret.bsky.social

🚨 Open position: A 2-year engineer/postdoc position will be available in Julie Soutourina’s group at #GenomeBiologyI2BC. The project focuses on Mediatorpathies, rare neurodevelopmental diseases, using yeast and human cell models with genomics and bioinformatics approaches. More info and contact 👇

Congratulations to you and all the authors! Excellent work from the #GenomeBiologyI2BC

Don’t miss the online journal of @i2bcparissaclay.bsky.social 📰. We publish the latest scientific news from all I2BC departments, including updates from #GenomeBiologyI2BC 🧬.
Take a look now!

I2BC Paris-Saclay

Last month of the year! 🎊 Amazing things happened at #GenomeBiologyI2BC
in 2024. Check out our #I2BC Scoop-it and see for yourself:
www.scoop.it/topic/i2bc-p...

Great work from the Namy team at #GenomeBiologyI2BC congratulations to all the authors!

How to tell a gene where and when it should be active? | I2BC Paris-Saclay A new study has dissected the complex interactions between regulatory layers that fine-tune the activity of a gene which is essential for the correct formation of the embryo. The formation of the embryo, from humans to flies, requires a precise orchestration of gene activity: genes need to be tur...

How to tell a gene where and when it should be active? | @scoopit@DaanNoordermeer, @LauraMoniot #GenomeBiologyI2BC

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New insights into genome annotation in Podospora anserina through re‑exploiting multiple RNA‑seq data | I2BC Paris-Saclay Thanks to multiple RNA-seq data available on public databases, we were able to improve the genome annotation on Podospora anserina and predict important regulatory features such as UTRs, alternative splicing and new transcription units. Publicly available RNA-seq datasets are often underused alth...

New insights into genome annotation in Podospora anserina through re‑exploiting multiple RNA‑seq data | @scoopit@glelandais @PierreGrognet
#GenomeBiologyI2BC

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Structural and functional characterization of DdrC, a novel DNA damage-induced nucleoid associated protein involved in DNA compaction | I2BC Paris-Saclay An unusual asymmetric domain-swapped dimer. Deinococcus radiodurans is a spherical bacterium well known for its exceptional resistance to DNA damaging agents. One of the DNA damage response genes specifically encoded by this bacterium, named DdrC, is expressed shortly after exposure to γ-radiatio...

Structural and functional characterization of DdrC, a novel DNA damage-induced nucleoid associated protein involved in DNA compaction | @scoopit@UnivParisSaclay
@timmins_joanna
@IBS_Grenoble #GenomeBiologyI2BC

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The Xer activation factor of TLCΦ expands the possibilities for Xer recombination | I2BC Paris-Saclay A phage-encoded protein known as XafT alters the sequence specificity of a crucial step in the accumulation of pathogenicity in the bacterium Vibrio cholerae. Our recent study investigated this interaction with an NGS-based approach. The chromosome dimer resolution machinery of bacteria is genera...

The Xer activation factor of TLCΦ expands the possibilities for Xer recombination | @scoopit@SolMiele, @jmsprovan #GenomeBiologyI2BC

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A Continuous Assay Set to Screen and Characterize Novel Protein N-Acetyltransferases Unveils Rice General Control Non-repressible 5-Related N-Acetyltransferase2 Activity | I2BC Paris-Saclay A new, robust continuous high-trough put test to screen and characterize new acetyltransferases. Protein N-acetyltransferases (NATs) belong to the general control non-repressible 5 (Gcn5)-related N-acetyltransferases (GNATs) superfamily. GNATs catalyze the transfer of acetyl from acetyl-CoA to th...

A Continuous Assay Set to Screen and Characterize Novel Protein N-Acetyltransferases Unveils Rice General Control Non-repressible 5-Related N-Acetyltransferase2 Activity | @scoopit@Giglionelab #GenomeBiologyI2BC

scoop.it/topic/i2bc-par…

The contribution of uncharted RNA sequences to tumor identity in lung cancer | I2BC Paris-Saclay Uncharted, unannotated RNAs contribute to cancer patient stratification and constitute novel theraputic targets. Cancer alters our RNAs in many ways, producing a wide diversity of aberrant RNAs of which many are specific to tumor types. Computational RNA sequence analysis in oncology typically fo...

The contribution of uncharted RNA sequences to tumor identity in lung cancer | @scoopit#RNA @Dgautheret #GenomeBiologyI2BC

scoop.it/topic/i2bc-par…

HubP-dependent cell pole organization in Vibrio cholerae | I2BC Paris-Saclay By comparative proteomics we identified several novel proteins localize to the cell pole in Vibrio cholerae. Characterization of these proteins revealed an ever more versatile role for the landmark cell pole organizer HubP and identify novel mechanisms of motility regulation. Cell polarity is the...

HubP-dependent cell pole organization in Vibrio cholerae | @scoopit@yamaichilab @krastevalab #GenomeBiologyI2BC

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Intergenic ORFs as elementary structural modules of de novo gene birth and protein evolution | I2BC Paris-Saclay Intergenic ORFs of S. cerevisiae encode the elementary building bricks of protein structures and can provide the raw material for de novo gene birth and protein evolution.  The noncoding genome plays an important role in de novo gene birth and in the emergence of genetic novelty. Nevertheless, ho...

#denovo @genomeresearch @anne__lopes @namyolivier @DSIMB_Lab #GenomeBiologyI2BC
Intergenic ORFs as elementary structural modules of de novo gene birth and protein evolution | @scoopit

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