#MSKResearch #BiomedicalDiscovery #GliomaResearch #CancerImmunology #GutMicrobiome #ScienceAdvances #CancerResearch

Multi-Layered Dysregulation of NRCAM in Gliomas: Insights from TCGA Copy Number and Epigenetic Analyses
Lehrer, S., Rheinstein, P. H.
Paper
Details
#GliomaResearch #NRCAMDysregulation #TCGAArchive

Congrats to Monika Pytlarz (@Sano - PhD candidate in computational neuroscience) for winning Best Oral Presentation at the 6th CEBC! Her SHAP-based AI method for glioma grading using HLA-DR–stained histology really stood out at the Young Investigator Session

Congrats to Monika Pytlarz (PhD candidate in Computational Neuroscience) for winning Best Oral Presentation at CEBC! 🎉
Her SHAP-based AI method for glioma grading using HLA-DR–stained histology stood out in the #YoungInvestigator session.
#Neuroscience #AIinMedicine #GliomaResearch #Sano

Response of Human Glioma U87 Xenografted on Mice to Non-Thermal Plasma Treatment

dl.begellhouse.com/journals/5a5...

#GliomaResearch #ColdPlasmaTherapy #CancerTreatment #InVivoStudy

Response of Human Glioma U87 Xenografted on Mice to Non-Thermal Plasma Treatment

dl.begellhouse.com/journals/5a5...

#GliomaResearch #ColdPlasmaTherapy #CancerTreatment #InVivoStudy

Programs, origins and immunomodulatory functions of myeloid cells in glioma | Nature Gliomas are incurable malignancies notable for having an immunosuppressive microenvironment with abundant myeloid cells, the immunomodulatory phenotypes of which remain poorly defined1. Here we systematically investigate these phenotypes by integrating single-cell RNA sequencing, chromatin accessibility, spatial transcriptomics and glioma organoid explant systems. We discovered four immunomodulatory expression programs: microglial inflammatory and scavenger immunosuppressive programs, which are both unique to primary brain tumours, and systemic inflammatory and complement immunosuppressive programs, which are also expressed by non-brain tumours. The programs are not contingent on myeloid cell type, developmental origin or tumour mutational state, but instead are driven by microenvironmental cues, including tumour hypoxia, interleukin-1β, TGFβ and standard-of-care dexamethasone treatment. Their relative expression can predict immunotherapy response and overall survival. By associating t

Uncover glioma's secrets! 4 myeloid cell programs identified in microenvironment: microglial, inflammatory, scavenger, immunosuppressive. #GliomaResearch PMID:40011771, Nature 2025, @Nature https://doi.org/10.1038/s41586-025-08633-8 #Medsky #Pharmsky #RNA 🧪

Single-molecule systems for the detection and monitoring of plasma-circulating nucleosomes and oncoproteins in diffuse midline glioma Erez et al. adapt single-molecule technologies to decode histone modification patterns on plasma-circulating nucleosomes from the blood of patients with pediatric high-grade glioma. They further devel...

New tech detects plasma nucleosomes & oncoproteins in 80% of diffuse midline glioma cases. #GliomaResearch PMID:39809263, Cell Rep Med 2025 www.cell.com/cell-reports...