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#HDACi
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Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
@sigtrans-sttt.bsky.social
2 months ago
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This #STTT study identified nucleus-localized PFKL as a key regulator of #HDACi efficacy and intracellular #Epigenetic dynamics in #Cholangiocarcinoma, positioning PFKL as a promising #TherapeuticTarget. @fudan-university.bsky.social

#OpenAccess: doi.org/10.1038/s413...

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Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
@sigtrans-sttt.bsky.social
5 months ago
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Insights into how nucleus-localized PFKL acts as a key regulator of #HDACi efficacy & intracellular #Epigenetic dynamics, highlighting it as a promising #TherapeuticTarget in #SolidTumors. @fudan-university.bsky.social

#OpenAccess: doi.org/10.1038/s413...

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Rene Sugar
Rene Sugar
@renesugar.bsky.social
8 months ago
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Clinical Trials for RGT-61159 | Rgenta Therapeutics Inc. | Boston, MA Join Rgenta's Phase 1a/b trial for RGT-61159, targeting advanced cancers. Contact us to learn about innovative treatment options.

eg.

Erlotinib ( #FOXA2; EGFR-TKIs)
RGT-61159 ( #MYB) www.rgentatx.com/clinical-tri...
Romidepsin ( #HDACi; #HDAC2)

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Molecular Oncology
Molecular Oncology
@moloncology.bsky.social
9 months ago
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The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl-xL or Mcl-1 in ovarian cancer

👉 buff.ly/Yt7gh6A

#HDACi #Belinostat
#OvarianCancer #CellDeath

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