HIF1α gates tendon response to overload and drives tendinopathy independently of vascular recruitment HIF1α activation promotes tendinopathy, and its inhibition prevents overload-induced maladaptation, suggesting therapeutic potential.

HIF1α gates tendon response to overload and drives tendinopathy independently of vascular recruitment | Science Translational Medicine www.science.org/doi/10.1126/...

Great collaboration with the de Bock Lab @ethz.ch

#tendon #tendinopathy #mechanobiology #HIF1a #ECM
@snsf.ch @ethz.ch @med.uzh.ch

Another lovely talk, this time from David Munro, about the context dependent roles for #HIF1a in #microglia, including in stroke #EMDS2025