TDP-43 skein-like inclusions are formed by BAG3- and HSP70-guided co-aggregation with actin-binding proteins - Nature Cell Biology Lu et al. show that, under proteotoxic stress, TDP-43 inclusions of skein-like morphology are guided by the chaperone HSP70 and its nucleotide exchange factor BAG3 to induce TDP-43 co-aggregation with F-actin-bound actin-binding proteins.

Product Citation 🌟

StressMarq's #HSP27 Antibody was used for proximity labeling-mass spectrometry @ucsandiego.bsky.social, which found that cellular stress induces BAG3-mediated #TDP43 inclusion formation.

Paper 💫 https://bit.ly/4ojR5HJ
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