Possible Disparity Between Objective, Subjective Autonomic Disease Burden in SM A major challenge in exploring the presumed link between mast cell activation syndromes and dysautonomia is the overlap of symptoms.

In patients with #SystemicMastocytosis, as well as those with #HereditaryAlphaTryptasemia and suspected #MastCellActivationDisorder, a potential discrepancy exists in their objective and subjective measures of autonomic disease burden severity.

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Interestingly #MCAS #HereditaryAlphaTryptasemia also associated with orthostatic brain hypoperfusion (&small fibre neuropathy) www.sciencedirect.com/science/arti...