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mTORC1 (Mechanistic Target of Rapamycin Complex 1) Signaling in Endothelial and Smooth Muscle Cells Is Required for Vascular Function mTORC1 (Mechanistic target of rapamycin complex 1) serves as a molecular hub and intracellular energy sensor that regulate various cellular processes. Emerging evidence points to mTORC1 signaling as

A complex role of mTORC1 in adult aorta contractility

#EndothelialCell (Tie2-CreERT2) Raptor KO
⏬ACh-, but not SNP-, induced vasodilation

#SmoothMuscleCell (SMMHC-CreERT2) Raptor KO
Abolished Ach-induced vasodilation
⏬SNP-induced vasodilation

#HyperAHA 2020
www.ahajournals.org/doi/10.1161/...