Effects of NAD+/NADH levels in disease pathophysiology and aging. An imbalance in the NAD+/NADH ratio generates reactive oxygen species, alters circadian rhythm, energy metabolism, inflammatory response and genome stability, and causes chronic metabolic diseases, cardiovascular and neurodegenerative diseases, aging, and cancer. NAD+, oxidized form of nicotinamide adenine dinucleotide; NADH, reduced form of nicotinamide adenine dinucleotide; ATP, adenosine triphosphate; and ROS, reactive oxygen species.
📰 Nampt: a new therapeutic target for modulating NAD+ levels in metabolic, cardiovascular, and neurodegenerative diseases
Read the full paper in this Canadian Journal of Physiology and Pharmacology collection ▶️ https://ow.ly/Yvqq50XqOeJ
📸 cjpp-2024-0400_fig1 #IACSNAS2023