INSM1: A highly sensitive marker for primary and metastatic Merkel cell carcinoma, superior to SOX11, pancytokeratin, and CK20 - PubMed Detection of Merkel cell carcinoma (MCC) micrometastases in sentinel lymph nodes (SLNs) often necessitates immunohistochemical studies like pancytokeratin (panCK) or CK20. However, panCK can label non-epithelial cells, particularly dendritic reticulum cells, complicating interpretation, while CK20 i …

Want to maximize Merkel cell carcinoma detection in sentinel lymph nodes? Go with panCK + INSM1 or panCK + SOX11. CK20’s sensitivity is just too low; its expression can be absent in up to 24% of MCCs. Check it out if you love #dermpath and #IHCpath. 😆🔬

#MDACCPath

pubmed.ncbi.nlm.nih.gov/40505699/

The evolving role of TRPS1 in dermatopathology: insights from the past 4 years - PubMed Over the past 4 years, trichorhinophalangeal syndrome type 1 (TRPS1) has rapidly gained attention among practicing pathologists, with numerous studies emerging that both support and question its diagnostic utility. Initially regarded as a highly specific marker for tumors of mammary origin, TRPS1 is …

Lastly, when in doubt, read this most comprehensive review on TRPS1 #IHCPath, which incorporates our extensive experience with this marker over the past 4–5 years in #dermpath. Free access! 😆🔬

#MDACCPath

pubmed.ncbi.nlm.nih.gov/41605620/

Here is another study supporting the role of TRPS1 #IHCPath in MPDs/EMPDs, which my initial studies proposed 2–3 years ago. Despite the major pushback and rejection from the #dermpath community at the time, I am glad to see more and more studies confirming our initial impression. 😆🔬

🚨 Hot off the press! The most comprehensive open-access review of TRPS1 and its applications in #dermpath is now available. Everything you need to know, based on our 4+ years of experience, is in one place. Check it out! 😆🔬

www.jpatholtm.org/journal/view...

#MDACCPath #IHCPath #TRPS1

It’s been a while since I shared a case.

Did you know this immunoprofile, especially the diffuse TRPS1 immunoreactivity, strongly favors primary EMPD over secondary EMPD? Give it a try if you haven’t used it in your practice. 😆🔬

#dermpath #IHCPath #MDACCPath

Just published! Check out this latest article!
🔵 PD-L1 expression showed high concordance between cores and full slides.
🔵 CD8+ T cell and CD68+ macrophage densities varied; cores underrepresented immune infiltrates.
@fabiotavora.bsky.social #IHCpath #lungcancer

🚨Spoiler alert: Primary cutaneous NUT adnexal carcinoma can metastasize—but long-term outcomes remain unclear. We're about to report an almost 20-year follow-up on this new entity. Stay tuned! 😆🔬🧬

#dermpath #pathology #molpath #IHCPath #MDACCPath

Just published! Check out this latest article 👉🏻 HER2 amplification is rare (1.7%) in low-grade, tubule-forming breast cancers with 2+ HER2 IHC; findings suggest ISH may be unnecessary in this subset #breastpath #IHCpath #pathsky

Telomerase Immunocytochemistry in Lymphocytes From Chronic Lymphocytic Leukemia

✨hTERT shows stronger nuclear staining in B-CLL cells vs. normal; linked to poor B-CLL prognosis #IHCpath #hemepath @katcollmd.bsky.social @ihc-guy.bsky.social
🔗 journals.lww.com/appliedimmun...

Shoutout to our amazing #MDACCPath #IHCPath team for making work fun! 😆🔬🎨🎉

We had an Easter egg hunt in the lab, and I got to decorate my microscope with the treasures I found. Wishing everyone a joyful Easter weekend! 🐣🪺

#pathology

It was almost a normal lymph node sample while #ROSE assessment, but...
▫️Epithelioid binucleated cell was too suspicious.
▫️Cytokeratin was positive on isolated cells.
▫️#CellBlock is always mandatory for #IHCPath.
▫️Medullary thyroid carcinoma Mx.
#HemePath #CytoPath #FNAFriday

📢 Exciting news! Thrilled to share I will be taking on the role of AIMM’s Social Media Editor! Grateful for this opportunity and excited to foster connections in the digital space and engage with our path community. #onlineaheadofprint #IHCpath
🔗 journals.lww.com/appliedimmun...

New Year #dermpath special! 😆🔬

What about a case of Merkel cell carcinoma showing diffuse DLL3 (delta-like protein 3) expression?

DLL3 is under investigation as a potential biomarker for DLL3-targeting antibody-drug conjugates.

#IHCPath #MDACCPath #pathology

Thursday #DermPath special! 😆🔬

Many tumors unfortunately can metastasize to the skin, including this one. 😫

Cutaneous metastasis of pancreatic adenocarcinoma showing complete loss of DPC4 expression.

#MDACCPath #pathology #GIpath #IHCpath