MTHFR allele and one-carbon metabolic profile predict severity of COVID-19 - PubMed While the public health burden of SARS-CoV-2 infection has lessened due to natural and vaccine-acquired immunity, emergence of less virulent variants, and antiviral medications, COVID-19 continues to take a significant toll. There are thousands of new hospitalizations and hundreds of deaths per week …

Our #IMPACC research in @pnas.org helps explain why people experience #Covid_19 so differently. @joanndarce.bsky.social @naama-kanarek.bsky.social @bostonchildrens.bsky.social @harvardmed.bsky.social @meduniwien.ac.at @yalemed.bsky.social @broadinstitute.org #NIAID

pubmed.ncbi.nlm.nih.gov/41410771/

his week, we are inspired by groundbreaking research from the IMPACC study, published in JCI. In their paper, “A multi-omics recovery factor predicts long COVID in the IMPACC study,”
Read here: www.jci.org/articles/vie...
#LongCOVID #LC #MultiOmics #Biomarkers #PrecisionMedicine #IMPACC

Screen shot of paper entitled "MICBG4064A polymorphism reduces risk of mechanical ventilation and death during viral acute lung injury." From JCI Insight publication.

More insights from #IMPACC studies, including polymorphism that might protect in #covid19 in online publication.
Authors include: @skleinstein.bsky.social @bjoernpeters.bsky.social @sesmalab.bsky.social @vivianasimonlab.bsky.social @joanndarce.bsky.social ++ others
insight.jci.org/articles/vie...

Great to see this work be published, it has been such a wonderful opportunity to be involved with the #IMPACC network - these important findings re immune response to #COVID will be useful for future pandemics especially for vulnerable populations @ast-idcop.bsky.social @niaidnews.bsky.social

Frontiers | Baseline predictors for 28-day COVID-19 severity and mortality among hospitalized patients: results from the IMPACC study IntroductionThe coronavirus disease 2019 (COVID-19) pandemic threatened public health and placed a significant burden on medical resources. The Immunophenoty...

Our collaborators identify chief predictor of #covid19 severity + death. Many authors include members of #IMPACC network: @rrmsky.bsky.social @bjoernpeters.bsky.social @skleinstein.bsky.social @sesmalab.bsky.social
@joanndarce.bsky.social @droferlevy.bsky.social
www.frontiersin.org/journals/med...

Identification of a multi-omics factor predictive of long COVID in the IMPACC study Following SARS-CoV-2 infection, ∼10-35% of COVID-19 patients experience long COVID (LC), in which often debilitating symptoms persist for at least three months. Elucidating the biologic underpinnings ...

Our manuscript on multiomics prediction of #LongCOVID is now up on bioRxiv! 🎉 Huge kudos to the entire #IMPACC Network, especially Lauren Ehrlich (UTex), Gisela Gabernet (Yale), and our incredible multiomics team for pushing this forward. Now, we wait! 🚀📑 #SystemsBiology #COVID19