Are you an IPNA Member? Just a quick reminder that you can access selected recordings from the #IPNA2025 Congress in Cape Town ▶️ www.theipna.org

#pedneph #education #membership

Two weeks ago, Matt touched down in Cape Town, South Africa, to attend the IPNA Congress. Thanks to everyone who presented and made it a great trip!

#IPNA2025
@kidneyomicsamps.bsky.social

Last week at #IPNA2025 in Cape Town, I ran a renal genetics workshop with an incredible group of paediatric nephrologists.

The enthusiasm was amazing—but so were the challenges. The global disparity in access to genetic testing is stark. Kids in some regions still can’t get a diagnosis. 🧵 2/4

#EmailsToDOGE
1. Spoke about Alport syndrome to international audience at #IPNA2025
2. Peer reviewed manuscripts x2
3. Cared for children with kidney disease
4. Review clinical trial enrollment and lab results
5. Brought my daughter to South Africa to learn about effects of apartheid first hand 🇿🇦

All patients with Dent’s (and presumably Lowe’s) Disease should be screened and treated for low vitamin A. This can drop because of loss of retinol binding protein and when severe can have permanent effects on their vision. #IPNA2025

Registry information: #IPNA2025

Patients with cystinuria are at risk of CKD and HTN.
Propensity to form stones and intensive treatment leads to impairment of quality of life.
#IPNA2025

Patients can monitor with urine dipsticks (pH and SG) at home.

Use of penicillamine or tiopronin can be limited by side effects (and cost for tiopronin). #IPNA2025

Diagnosis by stone analysis, urine amino acids (COLA), crystalluria (large, stacked hexagonal crystals), or crystals)
Treatment: hyper hydration, low salt and methionine (normal protein intake in children, no more than 1g/kg/day for adults). #IPNA2025

May present antenatally with echogenic bowel, however Fuchs et al recently described only 67% have cystiruria syndromes. #IPNA2025

Aurelia Bertholet Thomas speaking now on cystinuria.
Type A SLC3A1 is more common (and sometimes associated with a contiguous gene deletion including PREL1), and SLC7A9 less common. #IPNA2025

Nice summary slide. #IPNA2025

Treatment involves conservative measures (high fluids, low calcium and salt). Also azoles can inhibit CYP27B1 and rifampin can induce CYP3A4 to clear calcitriol. #IPNA2025

CYP24A1 deficiency can produce a very stubborn (albeit variable) stone forming nephropathy. Look for a raised 25-OHD:24-25-OHD. #IPNA2025

Emerging stone forming monogenic kidney diseases with David Sas from Mayo Clinic. #IPNA2025

Attending #IPNA2025? Join us this afternoon for talks by Dr. Michael Somers and Dr. Jodi Smith highlighting NAPRTCS Registry data.

Dr Julien Hogan presents results of RCT in children with FR nephrotic syndrome treated with Rituximab +/- IVIG. Result: Addition of IVIG showed no benefit on relapse free survival. #IPNA2025

After a touching opening ceremony and a great networking during the welcome cocktail, we are back at the Exhibition at #IPNA2025 (Booth #6) waiting for you to discuss everything #PeritonealDialysis and pediatrics: our fellowships, our guidelines, our next @ISPDCongress 2026 in Cape Town again!

Adolescent bladder clinic run in Sydney with nursing and psychology available. Achieved improvement in 60% patients!! #IPNA2025

Intravesical Botox can improve symptoms in about 60% of patients with mean duration of effect around 7 months. Risk of retention is low and patient can report when repeat therapy is required.
A potential option for non-adherence, like RTX is sometimes used in non-adherent FR SSNS. #IPNA2025

Gaya Raman presenting at the Bladder and Continence Grand Round. Rushing for the 7am start of this session I could certainly benefit from optimising my bladder capacity right now! #IPNA2025

ISPD president elect opening the IPNA 2025 Congress with a talk about Saving Young Lives.

Our President Elect Brett Cullis is honoured with a plenary talk during the Opening Ceremony of the #IPNA2025 Cape Town and explaining how #SavingYoungLives provides real world solutions to real world problems @theisn.org @ped-neph.bsky.social @ispd.org APSN SFNDT

Tammy Brady just gave the most outstanding interactive workshop on blood pressure measurement at #IPNA2025.
Things you mightn’t know can increase the blood pressure, crossed legs, watching the phone, TALKING!!

Promotional card. Contact Amy regarding content enquiries at a.slogrove@lancet.com. Copyright: Elsevier Ltd.

Attending #IPNA2025? Amy Slogrove, Senior Editor, invites you to reach out with enquiries. Explore our scope, reach & impact, commitment to publishing excellence, & more: hubs.li/Q01zB4HR0

Steroid minimisation. Are we slow to catch up to changes in adult practice? May improve adherence and side effects. #IPNA2025

Relapse: early treatment and CR important. Young at dx and AZT also risk factors. Important to remember risk of infection vs protection from relapse is a nuanced dance. #IPNA2025

Treatment for Class III/IV: whilst steroid and MMF is generally standard of care for children, suggestion of the need for early introduction of another steroid sparing agent (CNI or RTX) might be of benefit. Studies to come. #IPNA2025

Histology: whilst class of SLE is important, a move to consider activity and chronicity indices as well as remembering that as a rare and very complex disease, cookie cutter classification and treatment is ill advised. #IPNA2025

Key message: clinical features don’t accurately reflect renal histology. Low threshold for biopsy. #IPNA2025

Complex aetiology including susceptibility risk factors (genetic) and environmental triggers. #IPNA2025