#ISCs

📸 A look back at our Annual International Blockchain Scientific Conferences #ISCs 2018 - 2025.......

#Blockchain #Crypto #BBA

a black and white cartoon of mickey mouse reading a book on how to kill . ALT: a black and white cartoon of mickey mouse reading a book on how to kill .

Before assessing the relative roles of GSDMCs & ZBP1, we performed scRNAseq and found that in irradiated mice the transit amplifying & progenitor cells were expanded, while intestinal stem cells #ISCs contracted, in WT vs conditional KO mice, suggesting IFN-III kill #ISCs 7/n

PIEZO-dependent mechanosensing is essential for intestinal stem cell fate decision and maintenance Stem cells perceive and respond to biochemical and physical signals to maintain homeostasis. Yet, it remains unclear how stem cells sense mechanical signals from their niche in vivo. In this work, we ...

#LocationLocationLocation! Baghdadi, Kim &co show @science.org that intestinal stem cells #ISCs located at the bottom of the crypts sense a more rigid environment & activate PIEZO to tune their proliferation/differentiation maintaining gut physiology! doi.org/10.1126/scie...