Cell-type-targeted mitochondrial transplantation rescues cell degeneration - Nature MitoCatch is a cell-type-specific mitochondrion-targeting system that links mitochondria and the cell surface by protein binders and delivers mitochondria into the target cell.

#WeekendRead! #SharingIsCaring! #CatchMeIfYouCan! Roska, Ayupov, Moreno-Juan &co show @nature.com that healthy #mitochondria can be efficiently delivered to distinct cell types via a selective #MitoCatch system that allows their intracellular transfer & protection of cells!

🤔Do you think that OXPHOS in DCs = tolerance?
In our new @cp-cellmetabolism.bsky.social #cnic_cardio & @irbbarcelona.org, we show that active #mitochondrial ETC primes cDC1s for immunogenicity, not tolerance.
Life (& #immunometabolism) is not simple ⚡️
OPEN: www.cell.com/cell-metabol...
#immunoSky

#JoinUs! I’ll be presenting @aai.org #IMMUNOLOGY2026™ on Friday 4/17:
1) a new unpublished story on how to harness #innate anti-fungal responses to potentiate #adaptive immunity
2) how #Immunometabolism determines survival of the host during microbial encounter!

#JoinUs! I’ll be presenting @aai.org #IMMUNOLOGY2026™ on Friday 4/17:
1) a new unpublished story on how to harness #innate anti-fungal responses to potentiate #adaptive immunity
2) how #Immunometabolism determines survival of the host during microbial encounter!

Interferons in health and disease The cytokine messenger proteins known as interferons are central to protective immune responses against infections, but they are also involved in inflammatory and autoimmune diseases. This review maps...

My award for best stealth philosophical commentary on biology of the last few months goes to @lozanzi.bsky.social & Boehmer's use of quotes:

'Additionally, even one ‘‘cell type’’ can have a different PRR repertoire depending on its anatomic distribution within an organ or the age of the host'

Ahaahahaha thanks Thiago

My new comprehensive review of Immune Memory to Vaccines is out! It has an emphasis on human vaccines. It is also accompanied by a full video lecture. Enjoy!
@lji.org @cp-immunity.bsky.social
authors.elsevier.com/sd/article/S...

#WeekendRead! #EveryCellIsAnImmuneCell! #InflammasomePower! #ImmunometabolismPower! Zhao &co show @cp-cellhostmicrobe.bsky.social that a clostridium enriched in #IBD exacerbates colitis via boosting #glycolysis & IL1b by macrophages & activating NLRP3 in enteric #neurons, causing their loss!

Co‐Culture Systems to Study Epithelial‐Immune Interactions During SARS‐CoV‐2 Infection Robust inflammatory responses to viral infection are mediated by immune cell populations, including monocytes and dendritic cells. However, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2...

I've gotten lots of questions about our co-culture systems to study epithelial-immune interactions in viral infections, so wrote a step-by-step guide! I hope this will help anyone looking to adapt these protocols for their research.
currentprotocols.onlinelibrary.wiley.com/doi/abs/10.1...

Fantastic work @sergiocatz1.bsky.social & friends! #TollPower!! 👇👇👇

Great fun to write this review on Kupffer cells with Florent Ginhoux and Paul Kubes, covering origin, diversity and roles in immunity and metabolism, now out in @natrevimmunol.nature.com. Huge credit to Bruna Araujo David, Francesco Andreata and Camille Blériot for driving this work. t.co/rGpmTMRddV

📢CONFERENCE ANNOUNCEMENT!
#IMMA has just released numerous grants for students and postdocs!
🗓️Submission Deadline: Tuesday 12th May 2026
🔗Click here for more information: bit.ly/4tzNGYz

Many congrats!!! 💪💪💪

#WeekendRead! #EveryCellIsAnImmuneCell! Julius, Touhara &co show @nature.com that, during gut #elminth infections, tufts cells release acetylcholine in 2 waves to induce serotonine secretion by enterochromaffin cells, activating vagal nerve to suppress food intake! www.nature.com/articles/s41...

Abortive infection: T cells as early, antibody-independent defenders Nature Reviews Immunology - Neutralizing antibodies are widely viewed as the frontline of antiviral defence. Yet emerging evidence reveals that T cells can terminate infection before it is...

Neutralizing antibodies are not the whole story.

In our Comment in Nature Reviews Immunology, we highlight an alternative mode of protection:
👉 T cells can eliminate infection at its earliest stage — before it becomes detectable

We term this “abortive infection”

🔗 rdcu.be/fbq8p

Thread 1/4

NF-κB-activated fibroblasts orchestrate inflammaging and emergence of pro-inflammatory granzyme K+ T cells While inflammaging supposedly drives some of the most common diseases affecting the elderly, little is known about the tissue drivers of inflammaging.…

#WeekendRead! #EverycellIsAnImmuneCell! Allen, @ucsfpenglab.bsky.social &co show @cp-immunity.bsky.social that in #inflammaging, lung #fibroblasts activate NFkB & recruit monocytes/IMs that produce IL15 expanding dysfunctional CD8 T cells that drive excessive neutrophils, inflammation & lung damage!

Epigenetic memory of colitis promotes tumour growth - Nature Colonic stem cells retain a memory of inflammation following disease resolution and there is a mechanistic link between chronic inflammation and malignancy, suggesting potential strategies to mitigate...

#WeekendRead! #RemeberMe! @snaga13.bsky.social @jbuenrostro.bsky.social &co show @nature.com that intestinal stem cells remember multiple cycle of inflammation by epigenetically favoring AP-1 accessibility, thus increasing proliferation & repair, but also favoring tumorigenesis!

What an amazing day @mskcancercenter.bsky.social @cornelluniversity.bsky.social talking about inflammation, cell death, inflammasomes, B cells, lupus, fungi, & more! Thanks @diehllab-mskcc.bsky.social for hosting me, for a fantastic day of science & amazing dinner with @ilievlab.bsky.social & Randy🤗

Aspiring science communicators:
SCIENCE TALK '26 • Association of Science Communicators is happening in Portland next week!
If you don’t have time to attend the conference, but need a Friday evening activity, there will be a fun science cabaret show:
www.mcmenamins.com/events/27505...

Psoriasis modulates inflammatory bowel disease risk and intestinal epithelium lipid metabolism via IL-1β-producing macrophages Wu et al. reveal an inverse relationship between psoriasis severity and postprandial APOB48 levels in humans. Using a newly developed photoconvertible APOB knockin mouse and intestinal organoids, they...

#WeekendRead! #SkinGutAxis! Wu &co show @cp-cellmetabolism.bsky.social that #psoriasis induces a population of #intestinal macrophages that produce #IL1b & alters lipid absorption, increasing epithelial lipid accumulation, thus fostering gut inflammation!

Highly recommended 👇👇👇 Amazing PI, amazing research center, amazing #science!

MYC binding to nascent RNA suppresses innate immune signaling by R-loop-derived RNA-DNA hybrids In response to perturbed transcription elongation, the MYC oncoprotein multimerizes and undergoes a phase transition. Here, we demonstrate that MYC gl…

#WeekendRead #MysterySolved! MYC is one of the most famous #oncogenes & a potential therapeutic target but how does it work? Uhl, Eilers &co show @cp-cell.bsky.social that MYC binds introns during RNA stalling preventing export of dsRNA & DNA/RNA hybrids & anti-tumoral TLR3 activation!

A metabolic alarmin from keratinocytes potentiates systemic humoral immunity - Nature Farnesyl pyrophosphate—a mevalonate pathway metabolic intermediate—is an endogenous alarmin that enhances IgG antibody responses through keratinocyte-derived IL-6 and CCL20.

#WeekendRead! #ImmunometabolismPower! #EveryCellIsAnImmuneCell! Ji, Zhang, Lu, Liu &co show @nature.com that infection, irradiation, or lupus #SLE induce a mevalonate intermediates that drives IL6 & CCL20 by #keratinocytes via NFAT to potentate antibody production!

Thanks for sharing 🤗

Post-translational modifications of NLRP3: to prime or not to prime? The NLRP3 inflammasome plays a central role in host defense against microbial infections but also contributes to inflammatory diseases. Functioning of NLRP3 strictly relies on two signals: a ‘priming ...

'Over the past two decades, substantial progress has been made in understanding the regulation of #NLRP3. Priming, initially thought to be simply transcriptional, emerged as a complex interplay between different post-translational modificat'
O. Dufies & @lozanzi.bsky.social
#Immunology

Clinical development of cancer vaccines - Nature Medicine This Review highlights insights from recent clinical trials and discusses critical factors for optimizing cancer vaccines, with a focus on proxies for vaccine efficacy, neoantigen selection, modular p...

Want to know how cancer vaccines can keep you alive?
Very pleased to join several luminaries in the field to offer a comprehensive review on this important topic.
@harvardmed.bsky.social @bostonchildrens.bsky.social #cancer #vaccine
www.nature.com/articles/s41...

Flyer for CSHA Conference on Bacterial Infection & Host Defense

Deadline extended to March 27th for the CSHA conference on Bacterial Infection & Host Defense May 11-15, 2026! We have a fantastic list of speakers and opportunities for abstract talks. For full details, please visit the conference webpage: www.csh-asia.org?content/2975. Hope to see you in Suzhou!

Intestinal interoceptive dysfunction drives age-associated cognitive decline - Nature Age-related microbiome changes increase medium-chain fatty acid-producing bacteria, driving GPR84-mediated myeloid inflammation, impaired vagal signalling and hippocampal dysfunction; targeting this g...

#RememberMe! #MicrobiotaPower! @christophthaiss.bsky.social @maayanlevy.bsky.social Cox &co show @nature.com that microbial fatty acid-GPR84 driven intestinal inflammation initiates an actionable #GutBrainAxis that disrupts neuronal activation driving memory loss during #aging!

Commensal enteric virome regulates intestinal carbohydrate digestion and absorption The enteric microbiome and nutrient sensing within the small intestine play critical roles in maintaining host metabolic homeostasis. Although various…

#WeekendRead! #ViromePower! Lin, Li &co show @cp-cellhostmicrobe.bsky.social that the virome regulates sugar digestion & absorption by intestinal epithelial cells #IECs by favoring production of IL-22 via an antigen presenting cell-#Th17 axis!

Precancerous niche remodelling dictates nascent tumour persistence - Nature A study investigating the emergence of squamous tumours in the upper gastrointestinal tract of the mouse shows that an initial tumour stress response triggers fibroblasts to remodel the underlyin...

#WeekendRead! #SmartTumor! #EveryCellIsAnImmuneCell! Amazing work @nature.com by @mariapalcolea.bsky.social Skrupskelyte, Rojo &co showing the stress response driven by nascent tumors induces a wound healing program in surrounding fibroblasts driving a #PreCancerousNiche that fosters tumorigenesis!