Cell-type-targeted mitochondrial transplantation rescues cell degeneration - Nature MitoCatch is a cell-type-specific mitochondrion-targeting system that links mitochondria and the cell surface by protein binders and delivers mitochondria into the target cell.

#WeekendRead! #SharingIsCaring! #CatchMeIfYouCan! Roska, Ayupov, Moreno-Juan &co show @nature.com that healthy #mitochondria can be efficiently delivered to distinct cell types via a selective #MitoCatch system that allows their intracellular transfer & protection of cells!

🚀A potential paradigm shift for diseases linked to mitochondrial dysfunction.
📄 Published in Nature: www.nature.com/articles/s41...

#AcademicSky #MitoCatch #Mitochondria #CellBiology #Neurodegeneration #Blindness #PrecisionMedicine #BiomedicalResearch #ScienceCommunication #IOBBasel

✨Key findings: #MitoCatch delivers mitochondria to key cell types with higher efficiency. Transferred mitochondria remain functional and targeted cells’ survival is improved.

🔬 #MitoCatch uses engineered protein binders, like a cellular GPS, to guide mitochondria exactly where they are needed. Three complementary versions of #MitoCatch enable targeted delivery.

Targeted mitochondrial delivery: Extracellular donor mitochondria are delivered specifically to neurons via bispecific protein binders.

💡What if we could reboot sick cells?

IOB scientists @timayupov.bsky.social, @vmorenojuan.bsky.social and collaborators led by Botond Roska have developed #MitoCatch, a system that delivers healthy mitochondria directly to diseased cells. A step toward precision mitochondrial medicine.
Pic©IOB
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