#Medsky🧪 #Neurosky #immunosky #pedsky #publichealth The findings expand on those of the previous reported studies, by demonstrating that recessive variants in RNU2-2 cause a distinct & surprisingly prevalent disorder - recessive ReNU2 syndrome

Figure 1 from the paper: "Schematic representation of bioinformatics pipelines that implement computational modelling (mechanistic or Artificial Intelligence/Machine Learning driven) to develop Digital Twins for target identification and drug development for immune-mediated disorders. AI, artificial intelligence; DL, deep learning; DT, digital twins; ML, machine learning; ODE, ordinary differential equation."

🆕 review! Anna Niarakis and Philippe Moingeon explore how #DigitalTwin technology can accelerate precision medicine for immune-related pathologies. They highlight recent advances and outline future directions for the field.

#Immunosky

#Medsky🧪 #IDsky #immunosky #episky #publichealth
Nearly 5 years after #COVID began ~ 5.3% of 🇺🇸 adults were experiencing #LongCOVID ; 1-in-4 of them consistently report significant activity limitations from its symptoms Disability accounts for most LC diseases burden,

@cleeterichter.bsky.social will present this preprint today in #preprinthub2! ⚡️🚦🐁 #immunosky @ucsdhealthsci.bsky.social

New Journal for ImmunoTherapy of Cancer article: "Intratumoral PD-1-directed IL-2 expression via oncolytic vaccinia virus elicits superior antitumor effects with enhanced safety" https://jitc.bmj.com/content/14/3/e011340🧪

New Journal for ImmunoTherapy of Cancer article: "Intratumoral PD-1-directed IL-2 expression via oncolytic vaccinia virus elicits superior antitumor effects with enhanced safety" jitc.bmj.com/content/14/3...

#JITC #immunosky

Infographic

#Medsky🧪#IDsky #immunosky #publichealth The study find different individual #Mycobacterium #tuberculosis antigens induce distinct #Tcell responses, with important implications for TB #vaccine development.
@insight.jci.org
insight.jci.org/articles/vie...

#Medsky🧪 #IDsky #Immunosky #publichealth PDLIM2, a PDZ-LIM domain-containing protein expressed highest in the lung and immune cells, serves as a unique tumor suppressor & immune modulator,

#Medsky🧪 #iDsky #immunosky #Publichealth This trial addresses a critical gap in #LongCOVID management by providing the largest source of evidence to guide medical care for #POTS in LC patients
- Specific Interventions & Their Rationale
N

FEBS Press Using 1H NMR metabolomics, we measured polar and lipid metabolites from human blood neutrophils from people with frailty (n = 31, mean age 84Y), people with rheumatoid arthritis (n = 16, mean age 55Y...

New paper from @gnna.bsky.social investigating altered neutrophil metabolism in healthy ageing & frailty. We found signatures of neutrophil activation, lipid metabolism & oxidative stress. #immunosky
@vivensa.bsky.social @livuni-ilcams.bsky.social

febs.onlinelibrary.wiley.com/doi/10.1111/...

Glibenclamide attenuates neuronal #pyroptosis by modulating KATP channels in the hippocampus of palmitic acid-induced lipotoxic mice

www.sciencedirect.com/science/arti... #OpenAccess #inflammasome #inflammation #immunology #ImmunoSky #MedSky

Disease-Attenuated Pneumococcal Biosynthesis Gene Mutants Invade the Mucosal Epithelium and Induce Innate Immunity Mutations in Streptococcus pneumoniae biosynthesis genes had impacts on virulence, oxidative stress, and metabolism. Mutants retained their microinvasive a

Epithelial host pathogen interactions are complex!

Happy to have contributed to this work, showing how mutations in Streptococcus pneumoniae biosynthesis genes results in divergent phenotyoic effects and host transcriptional responses (the bit I did!)

#IDSky #immunosky

@jidjournal.bsky.social

Call for reviewers. Become an ad hoc reviewer for the BSI journals. British Society for Immunology. Oxford University Press.

Discover benefits available when you become a peer reviewer for the @britsocimm.bsky.social journals, including a chance work with immunology experts to advance research.

🔗 oxford.ly/4sz3vPa

#ImmunoSky @ceijournal.bsky.social @imtadvances.bsky.social @discovimmunol.bsky.social

#Medsky🧪 #IDsky #Immunosky #publichealth #Longcovid & inflammation .
Across the retrieved evidence, there is clear support for a mechanistic link between elevated BMI, reduced gray matter volume (GMV), and peripheral inflammation in #postCOVID condition (PCC).

#Medsky🧪 #IDsky #immunosky #publichealth This study reveals that #SARSCoV2 nonspike structural proteins— specifically the Envelope (E), Membrane (M) & Nucleocapsid (N) proteins—directly hijack mucosal epithelial cell fate through a "double hijack" mechanism.

Early Detection and Surveillance of the SARS-CoV-2 ... This report describes early detection and surveillance ...

#Medsky🧪 #IDsky #immunosky The #SARSCoV2 variant BA.3.2, a highly divergent lineage of the Omicron variant, was first detected in South Africa .it has been reported in at least 23 countries worldwide, following a notable ⏫️ in detections starting in Sep 2025.

www.cdc.gov/mmwr/volumes....

Here here for retiring an often overgeneralized M1-M2 binary phenotypic framework. #macrophages express an incredible large array of sensome receptors that allow them to tailor their phenotype and reactions to the needs of incredibly local environments. #neuroskyence #immunosky #glia

Awesome discussion for those of us who love resident #macrophages in all their forms, and wonder what allows some to be be self renewing
#neuroskyence #immunosky #glia #neuroinflammation

Masters by Research in Biological Sciences at Royal Holloway Explore our internationally-renowned masters with specialist staff and breakthrough research

🧪 I am offering cardiovascular projects as part of @royalholloway.bsky.social MSc in Biological Sciences research from effects of air pollution to creating 3D human vascular models. Contact me if interested. www.royalholloway.ac.uk/research-and...
#immunosky #cardiosky #academicsky #academicchatter

Cell Symposia: Host-microbiome dynamics

May 10–12, 2026 | Bruges, Belgium

www.cell-symposia.com/microbiome-2... #Research #microbiota #microbiome #microbiology #MicroSky #ImmunoSky

New study reveals how blood cell production responds to parasite infection Research led by the Nerlov Group in the MRC Molecular Haematology Unit provides the first detailed explanation of how parasite-fighting immune cells are selectively increased following infection.

New research provides the first detailed explanation of how parasite-fighting immune cells are selectively increased following infection. 🦠 https://bit.ly/4sYRAde

#ImmunoSky @imm.ox.ac.uk @nature.com

Immunogenicity and efficacy over 12 months following a fourth dose of a bivalent mRNA or protein-based COVID-19 vaccine: A randomised controlled trial in Australia We report immunogenicity, safety, and efficacy over 12 months following a fourth COVID-19 mRNA or protein vaccine dose.

#Medsky🧪 #IDsky #immunosky #publichealth This RCT compared the long-term immunogenicity efficacy of 4th-dose #COVIDvaccines in 🇦🇺 over 12 months .
www.journalofinfection.com/article/S016...

A sympathetic-eosinophil axis orchestrates psychological stress to exacerbate skin inflammation Psychological stress is believed to exacerbate dermatitis, yet the neurobiological mechanisms linking stress to immune processes remain elusive. We identified a subset of prodynorphin-positive (Pdyn+)...

Very cool 😎 !

This study identifies the neuronal circuit that translates psychological stress (a feeling) into skin inflammation leading to eczema flare-ups

www.science.org/doi/10.1126/...
🧪 #immunosky

#immunology #immunosky #Bcell #immunogenetics

Evidence of White Matter Neuroinflammation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Diffusion‐Based Neuroinflammation Imaging Study Diffusion-based neuroinflammation imaging (NII) reveals widespread white matter abnormalities in ME/CFS patients, undetected by conventional DTI. NII metrics associate with mental health, disability ...

#MedSky🧪 #Neurosky #immunosky #IDSky #publichealth The study provides significant in vivo evidence of white matter neuroinflammation in ME/CFS by using advanced diffusion-based neuroinflammation imaging (NII)

onlinelibrary.wiley.com/doi/full/10....

International Journal of Clinical Oncology

A new #OpenAccess study in 'International Journal of Clinical Oncology' finds no evidence of molecular mimicry between HPV vaccine L1 antigen and human proteins, challenging claims that HPV vaccination could trigger cross-reactive autoantibodies. bit.ly/3PujMWJ #ImmunoSky #MedSky

Fat tissue fuels gut inflammation Researchers at the Max Delbrück Center and Charité – Universitätsmedizin Berlin show that adipose tissue amplifies gut inflammation in Crohn’s disease. The study, published in the “Journal of Clinical...

Scientists from @mdc-berlin.bsky.social show that fat tissue releases signals that ultimately damage the intestinal barrier in Crohn’s disease. They also show that acquired genetic mutations in immune cells may fuel the disease. 🥼 #ImmunoSky https://bit.ly/4uDxeHV

#Medsky🧪 #IDsky #immunosky #publichealth Pneumococcal disease is caused by #Streptococcuspneumoniae, an encapsulated, Gram-positive bacterium. Pneumococcal disease can be classified as non-invasive (community-acquired pneumonia [CAP], #sinusitis & #acuteotitismedia) or invasive

#Medsky🧪 #IDsky #immunosky #publichealth In this review *The "renaissance" of antiviral CD8+ T cell immunity refers to the renewed scientific focus on these cells as primary drivers of long-term protection and disease control. While vaccine development has historically prioritised antibody responses

Targeting endosomal trafficking-mediated antigen escape to resensitize myeloma to CAR-T therapy Background Antigen escape is one of the leading causes of relapse following chimeric antigen receptor (CAR)-T therapy, particularly in multiple myeloma. A critical gap persists in understanding the tu...

New Journal for ImmunoTherapy of Cancer article: "Targeting endosomal trafficking-mediated antigen escape to resensitize myeloma to CAR-T therapy" jitc.bmj.com/content/14/3...

#JITC #research #ImmunoSky

Antti Hurme Turun Immunologiakeskuksen kliiniseksi johtajaksi – tavoitteena tutkimuksen ja klinikan yhdistäminen - InFLAMES-lippulaiva Lääketieteen tohtori Antti Hurme aloitti Turun Immunologiakeskuksen kliinisenä johtajana helmikuussa 2026. Hän sanoo, että immunologiakeskus on juuri se mitä tarvitaan, jotta immunologista perustutkim...

Lääketieteen tohtori Antti Hurme on aloittanut Turun Immunologiakeskuksen kliinisenä johtajana! Hän aikoo toimia siltana immunologisen perustutkimuksen ja klinikan välillä.
Onnea Antille!
#ImmunoSky #MedSky #ScienceSky