Intestinal interoceptive dysfunction drives age-associated cognitive decline - Nature Age-related microbiome changes increase medium-chain fatty acid-producing bacteria, driving GPR84-mediated myeloid inflammation, impaired vagal signalling and hippocampal dysfunction; targeting this g...

#RememberMe! #MicrobiotaPower! @christophthaiss.bsky.social @maayanlevy.bsky.social Cox &co show @nature.com that microbial fatty acid-GPR84 driven intestinal inflammation initiates an actionable #GutBrainAxis that disrupts neuronal activation driving memory loss during #aging!

Intestinal epithelial TLR5 signaling promotes barrier-supportive macrophages Colonic stem cell TLR5 sensing of microbes promotes macrophage recruitment and maturation to support intestinal barrier repair.

#WeekendRead #MicrobiotaPower! Tsai, @diehllab.bsky.social &co show @ Science Immunology that E. coli flagellin is recognized by TLR5 on intestinal epithelial stem cells to recruit gut protective CCR2+ monocyte-derived macrophages, decreasing colitis! #IBDs doi.org/10.1126/sciimmunol.adr4057

Dietary fibre-adapted gut microbiome clears dietary fructose and reverses hepatic steatosis - Nature Metabolism The dietary fibre inulin is shown to promote fructose catabolism by the small intestinal microbiome, thereby mitigating fructose-induced hepatic lipogenesis and steatosis.

#WeekendRead! #MicrobiotaPower! Jang, Jung &co show @natmetabolism.nature.com that dietary fibre protects against dietary fructose-driven insulin resistance & liver steatosis via promoting fructose utilization by small intestine microbiota & favoring anti-oxidant responses in the liver!

Gut microbe-derived metabolites drive psoriatic inflammation via modulation of skin Th17 cells Wang et al. demonstrate that gut rather than skin microbiota promote skin inflammation in a spontaneous psoriasis mouse model by fueling the production of the metabolite indoxyl sulfate (I3S). I3S amp...

#WeekendRead! #MicrobiotaPower! Wang, Lin &co reveal @immunity-cp.bsky.social that a #GutSkinAxis that drives skin inflammation in psoriatic prone mice & patients caused by indole-producing gut bugs that increase host I3S driving AHR-dependent skin Th17 activation! www.cell.com/immunity/abs...

Acetylated cellulose suppresses body mass gain through gut commensals consuming host-accessible carbohydrates The benefits and mechanisms of prebiotics that target the gut microbiota in treating obesity remain poorly understood. Takeuchi et al. report that acetylated cellulose promotes fatty acid oxidation an...

#WeekendRead! #WeAreWhatWeEat, #MicrobiotaPower! Takeuchi, Ohno &co show @cp-cellmetabolism.bsky.social that acetylated cellulose reduces body weight gain in lean & obese mice by favoring utilization of simple sugars by the microbiota, forcing hepatic fatty acid utilization! dlvr.it/TMKzHY

Microbiota-derived inosine programs protective CD8+ T cell responses against influenza in newborns Stevens et al. reveal that antibiotic-induced microbiome disruption impairs infant antiviral immunity by reducing inosine levels, which disturbs CD8+ T cell programming. Remarkably, Bifidobacterium co...

#WeekendRead! #MicrobiotaPower! Deshmukh Stevens &co show @cp-cell.bsky.social that antibiotics in infant mice & humans decreases gut microbiota-driven inosine dampening anti-influenza A virus CD8 T cell effector functions & Trm formation in the lung via altered epigenetic reprogramming #GutLungAxis

CD4 T cell therapy counteracts inflammaging and senescence by preserving gut barrier integrity Treg cells safeguard the intestinal barrier to prevent inflammaging and senescence in a mouse model of premature aging.

#WeekendRead! #LiveForever & #MicrobiotaPower! Mittelbrun &co show @ Science Immunology that mitochondria alteration in T cells drives premature #inflammaging by decreasing Tfh & Treg cells which causes gut permeability & dysbiosis that can be corrected by T cell transfer! doi.org/10.1126/scii...

Imidazole propionate is a driver and therapeutic target in atherosclerosis - Nature Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the imidazoline-1 ...

#MicrobiotaPower, #FriendOrFoe? @sancholab.bsky.social Mastrangelo &co show @nature.com that a microbiota-derived metabolite drives #atherosclerosis in athero-prone mice in the absence of high fat diet or high cholesterol by acting directly on myeloid cells! www.nature.com/articles/s41...

Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy Exercise enhances antitumor immunity and immunotherapy effectiveness by increasing microbiota-derived formate, which boosts CD8 T cell function and may serve as a biomarker of melanoma suppression.

#MicrobiotaPower via #Exercise! Phelps, Meisel &co show @cp-cell.bsky.social that exercise drives formate from microbiota that in turns activates NRF2 in CD8 T cells driving STAT1/IRF8 programs that potentiate immune checkpoint inhibitor efficacy against #melanoma! dlvr.it/TLqLW7

Bacteroides sphingolipids promote anti-inflammatory responses through the mevalonate pathway Brown et al. show that bacterial sphingolipids delivered by outer membrane vesicles (OMVs) persist within mammalian immune cells and promote IL-10 secretion via the mevalonate pathway. This sphingolip...

#WeekendRead #MicrobiotaPower! @thexavierlab.bsky.social @emilytemplewood.bsky.social &co show @cp-cellhostmicrobe.bsky.social that gut bacteriodes produce outer membrane vesicles enriched in sphingolipids which drive anti-inflammatory IL-10 by dendritic cells via cholesterol synthesis pathways!

IL-10 sensing by lung interstitial macrophages prevents bacterial dysbiosis-driven pulmonary inflammation and maintains immune homeostasis Immune-microbiota interactions are required to maintain host homeostasis. Kim et al. identified that steady-state sensing of IL-10 by interstitial macrophages (IMs) prevents spontaneous lung inflammat...

#IL10power & #MicrobiotaPower! Kim, Kim, Sano &co show @cp-immunity.bsky.social that lung interstitial macrophages lacking IL10 signaling drive chronic inflammation that depends on monocytes, Th17 T cells, & dysbiosis!
dlvr.it/TKRndF

Vaccine-enhanced competition permits rational bacterial strain replacement in the gut Colonization of the intestinal lumen precedes invasive infection for a wide range of enteropathogenic and opportunistic pathogenic bacteria. We show that combining oral vaccination with engineered or ...

#WeekendRead! #MicrobiotaPower! @mucosalimmunology.bsky.social Diard Lentsch &co show @science.org oral vaccination combined with a pathogen competitor microbial strain prophylactically or therapeutically protects against Salmonella or Coli via competing for energy substrates & CD4 T-dependent IgA!

Colonic goblet cell-associated antigen passages mediate physiologic and beneficial translocation of live gut bacteria in preweaning mice - Nature Microbiology Colonic goblet cell-associated passages allow translocation of live bacteria to other organs in early life, potentially leading to beneficial impacts.

#MicrobiotaPower #AgainstDogma. Udayan, Newberry &co show @naturemicrobiol.bsky.social that, during early life, goblet cells allow a controlled spread of microbiota species that do not induce inflammation & instead protect in adult life against sepsis. #ScienceMatters www.nature.com/articles/s41...

Enterobactin inhibits microbiota-dependent activation of AhR to promote bacterial sepsis in mice - Nature Microbiology Bacterial pathogens produce enterobactin, which suppresses microbiota-derived indole activation of Ahr in macrophages to inhibit bacterial clearance and increase the severity of bacterial sepsis.

#MicrobiotaPower! Keskey Alverdy &co show @naturemicrobiol.bsky.social that gut microbiota-derived indoles activate AhR in macrophages, protecting against #sepsis! Bacterial pathogens can produce a siderophore that inhibits AhR increasing sepsis mortality! www.nature.com/articles/s41...

Enteric bacterial infection stimulates remodelling of bile metabolites to promote intestinal homeostasis - Nature Microbiology Metabolomic analysis of bile after infection by enteric bacteria in mice reveals composition changes including increased itaconate levels that promote intestinal homeostasis and reduce Vibrio cholerae...

#MicrobiotaPower @ Thanksgiving 🦃! Zhang, Waldor &co show @ Nature Microbiology that microbiota & enteric infections modulate the nature of bile metabolites via an intestine-liver axis & that itaconate in the bile protects against Vibrio cholerae! www.nature.com/articles/s41...

Gut microbiota regulates stress responsivity via the circadian system Gut microbes are known to modulate stress responsivity and behavior. Tofani et al. demonstrate that such modulations occur via the circadian system. The oscillations in gut microbiota composition regu...

#WeekendRead! #MicrobiotaPower! #RelexDoNotStress! Tofani @jfcryan.bsky.social &co show @Cell_Metabolism that the microbiota “regulates stress responsiveness in a circadian manner and is necessary to respond adaptively to stressors throughout the day”! tinyurl.com/bdd98e6a

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#WeekendRead! #MicrobiotaPower! Zhou, Li &co show @ Cell Metabolism that in rheumatoid arthritis #RA food intake drives glycitein by the microbiota that via sirtuin-5 inhibits inflammation! Inflammation in RA is rhythmic & is influenced by dietary patterns! doi.org/10.1016/j.cm...