Finally, my PhD project is published! 🎉

I am thankful to all the collaborators who made this possible!

www.nature.com/articles/s41...

@natcomms.nature.com
#dendriticcells #immunesynapse #centrosome

Nuclear polarization to the immune synapse facilitates an early transcriptional burst Cytotoxic T lymphocyte target recognition triggers rapid nuclear polarization to the immune synapse and an early transcriptional burst of cytokines.

Now in #Science #Immunology: @griffithslab.bsky.social report that when #CD8 #TCells encounter their targets, #nucleus localizes to the #ImmuneSynapse (IS) & facilitates delivery of newly synthesized cytokines to the IS. They find nuclear polarization represents key step in #CTL -mediated killing!

Nanoscale restructuring of the immune synapse with an engager enhances NK cell function | PNAS Engagers are antibody-based therapies which bind immune cell receptors and a target cell ligand. Next-gen engagers typically bind two activating re...

Our new paper, in collaboration with Bristol Myers Squibb, on a Natural Killer cell immune therapy, is just published here:

www.pnas.org/doi/10.1073/...

#immunesynapse #nkcells #immunetherapy #microscopy