Welcome, Prof. Dr. Linda Brunotte, to the Pulmonary Infections team! Her cutting-edge research unravels the complex battle between influenza viruses and the human immune system, focusing on innovative models to explore lung infection mechanisms and develop new antiviral therapies. Excited to have her advancing our understanding and treatment of respiratory diseases! #PulmonaryInfections #ResearchWelcome #InfluenzaResearch

Welcome, Prof. Dr. Linda Brunotte, to Pulmonary Infections!

Her cutting-edge research unravels the complex battle between influenza viruses & the human immune system.

Excited to have her advancing our understanding & treatment of respiratory diseases!

#PulmonaryInfections #InfluenzaResearch

1/11 🚨🦠 ALARMING: SEASONAL FLU VACCINES OFFER ZERO PROTECTION AGAINST H5N1 🦠🚨

New Canadian research shows no cross-immunity between seasonal flu and deadly H5N1 strains, despite 50% fatality rate.

Open Forum Infectious Diseases reports.
#H5N1 #InfluenzaResearch #PandemicPreparedness #PandemicRisk

Congratulations, Dr. Theresa Schäfer!

Theresa successfully defended her PhD thesis, “The Impact of GM-CSF on Lung Epithelial Cell Injury and Repair in Severe Influenza Virus Pneumonia.”

We are proud to celebrate this milestone with you!

#PhDDefense #MedicalResearch #InfluenzaResearch #LungHealth

Receptor-binding specificity of a bovine influenza A virus - Nature Nature - Receptor-binding specificity of a bovine influenza A virus

Congratulations to the research team on their recent publication in Nature, titled "Receptor-binding specificity of a bovine influenza A virus" 💯🦠🐮 @smtflu.bsky.social
#InfluenzaResearch #CollaborativeScience @ugaresearch.bsky.social www.nature.com/articles/s41...

1/9 🚨FLU CIRCULATES IN CATTLE🚨

A large study reveals nearly 34% of U.S. cattle test positive for influenza A antibodies.

Indicating widespread exposure to human seasonal flu strains and swine viruses.
#AnimalHealth #InfluenzaResearch

GGCX promotes Eurasian avian-like H1N1 swine influenza virus adaption to interspecies receptor binding | Nature Communications The Eurasian avian-like (EA) H1N1 swine influenza virus (SIV) possesses the capacity to instigate the next influenza pandemic, owing to its heightened affinity for the human-type α-2,6 sialic acid (SA) receptor. Nevertheless, the molecular mechanisms underlying the switch in receptor binding preferences of EA H1N1 SIV remain elusive. In this study, we conduct a comprehensive genome-wide CRISPR/Cas9 knockout screen utilizing EA H1N1 SIV in porcine kidney cells. Knocking out the enzyme gamma glutamyl carboxylase (GGCX) reduces virus replication in vitro and in vivo by inhibiting the carboxylation modification of viral haemagglutinin (HA) and the adhesion of progeny viruses, ultimately impeding the replication of EA H1N1 SIV. Furthermore, GGCX is revealed to be the determinant of the D225E substitution of EA H1N1 SIV, and GGCX-medicated carboxylation modification of HA 225E contributes to the receptor binding adaption of EA H1N1 SIV to the α-2,6 SA receptor. Taken together, our CRISPR scr

GGCX facilitates EA H1N1 SIV adaptation by boosting α2,6 sialic acid receptor binding. CRISPR screen reveals insights crucial for pandemic surveillance. #InfluenzaResearch PMID:39809757, Nat Commun 2025, @NatureComms @OTSociety https://doi.org/10.1038/s41467-025-55903-0 #Medsky 🧪