Medical News cover for 'Research of the Year 2025' in JAMA. Collage includes heart illustration, shingles patient, tech circuit board, mother & baby, elderly in wheelchairs, blood bag with figures inside, pink ribbon with diverse faces, vaccination shot, and medication illustration.

Introducing JAMA’s Research of the Year. #JAMAROTY25

Chosen by JAMA editors, the inaugural roundup highlights 9 of the most impactful, newsworthy, and novel studies published in the journal over the past year:

Learn more: ja.ma/4rN3jM1

Our P3 Launch-HTN trial of lorundrostat - the largest trial of an aldosterone synthase inhibitor conducted among participants with uncontrolled or treatment-resistant hypertension - was featured in JAMA’s inaugural “Research of the Year” article!
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#JAMAROTY25

Research of the Year 2025 This Medical News article is an editor’s choice roundup of the most impactful, newsworthy, and novel studies published in JAMA over the past year.

Results from @alzassociation.bsky.social’s U.S. POINTER lifestyle intervention trial were named to @jama.com’s Research of the Year roundup—recognizing its rigor and relevance for clinicians and health systems advancing evidence-based dementia risk reduction. #JAMAROTY25 ja.ma/4j3tdar

Proud moment for brain health research. 🧠
Results from the Association’s landmark U.S. POINTER lifestyle intervention trial were named to @jama.com’s Research of the Year roundup—highlighting its impact on the future of brain health. Grateful to the researchers, participants and donors. #JAMAROTY25

#JAMAROTY25: Semaglutide and Tirzepatide in Patients with HFpEF

#Semaglutide and #Tirzepatide were both associated with a more than 40% lower risk of heart failure hospitalization or all-cause death in patients with cardiometabolic #HFpEF compared with a placebo proxy.

🔗 ja.ma/48BSc1a

#JAMAROTY25: US POINTER Randomized Clinical Trial

Among older adults with #dementia risk factors, structured lifestyle support led to greater improvements in global cognition than self-guided changes.

🔗 ja.ma/3MtCgW5

#JAMAROTY25: Launch-HTN Randomized Clinical Trial

In adults with uncontrolled #hypertension taking multiple antihypertensive medications, the aldosterone synthase inhibitor lorundrostat safely lowered systolic blood pressure compared with placebo.

🔗 ja.ma/4adm19k

#JAMAROTY25: Herpes Zoster Vaccination and Dementia Occurrence

Eligibility for #herpes zoster vaccination based on date of birth was associated with a reduction in the probability of receiving a new diagnosis of #dementia over a 7.4-year follow-up.

🔗 ja.ma/4ack9Oc

#JAMAROTY25: GUARDIAN study

Targeted genome sequencing for #NewbornScreening enabled early detection of treatable conditions missed by standard tests, with broad parental consent and successful delivery across diverse groups.

🔗 ja.ma/49crLhF

#JAMAROTY25: Testing and Evaluation of Health Care Applications of Large Language Models

#AI in health care is rapidly expanding, but there are major gaps in how these #LLM applications are assessed; many overlook performance on administrative tasks and measures of bias.

🔗 ja.ma/4pzEX7a

#JAMAROTY25: The TRAIN Randomized Clinical Trial

In patients with acute brain injury and anemia, a more liberal red blood cell transfusion strategy improved neurological outcomes compared with a restrictive strategy.

🔗 ja.ma/4aRzBzk

#JAMAROTY25: The BEe-HIVe Randomized Clinical Trial

In people with #HIV who didn’t respond to prior #HepB vaccination, a vaccine with a novel adjuvant provided better seroprotection than the conventional vaccine.

🔗 ja.ma/4iQ4HJH

#JAMAROTY25: The COMET Randomized Clinical Trial

Active monitoring for low-risk #DCIS was noninferior to standard treatment over 2 years, with similar rates of invasive cancer and fewer mastectomies compared with guideline-concordant care.

🔗 ja.ma/4iSPTKh

Introducing JAMA’s Research of the Year.

Chosen by JAMA editors, the inaugural roundup highlights 9 of the most impactful, newsworthy, and novel studies published in the journal over the past year. 🧵

#JAMAROTY25

🔗 ja.ma/4pAihne