Journal of Comparative Effectiveness Research

@journal-cer.bsky.social

1 month ago

Treatment burden and healthcare resource utilization in patients with chronic rhinosinusitis with nasal polyps who did or did not undergo functional endoscopic sinus surgery: a US real-world retrospec... Aim: To compare oral corticosteroid (OCS) burden and healthcare resource utilization (HCRU) in patients with chronic rhinosinusitis with nasal polyps undergoing functional endoscopic sinus surgery (FE...

📢New article alert

Treatment burden and healthcare resource utilization in patients with chronic rhinosinusitis with nasal polyps who did or did not undergo functional endoscopic sinus surgery: a US real-world retrospective cohort study

🔗 becarispublishing.com/doi/10.57264...

#OpenAccess #JCER

Journal of Comparative Effectiveness Research

@journal-cer.bsky.social

1 month ago

Sieving for gold: external comparator studies to prioritize drugs for late-stage clinical trial External comparator (EC) studies can improve identification of compounds with the most promising performance in pre-pivotal single-arm trials (SAT). As SAT output lacks comparative insights, EC studie...

📢New article alert

New Perspective article on "Sieving for gold: external comparator studies to prioritize drugs for late-stage clinical trial"

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#OpenAccess #JCER #TrialMethodology #RealWorldEvidence #RWE

Journal of Comparative Effectiveness Research

@journal-cer.bsky.social

1 month ago

Indirect comparisons of tucatinib in combination with trastuzumab for patients with previously treated HER2–positive metastatic colorectal cancer Aim: In the single-arm MOUNTAINEER trial (NCT03043313) tucatinib in combination with trastuzumab showed an objective response rate (ORR) of 39.3% in patients with previously treated, HER2+ unresectabl...

📢New article alert

New Research Article on “Indirect comparisons of tucatinib in combination with trastuzumab for patients with previously treated HER2–positive metastatic colorectal cancer”.

🔗Read here: becarispublishing.com/doi/10.57264...

#OpenAccess #JCER #ColorectalCancer #Oncology #ITC

Journal of Comparative Effectiveness Research

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2 months ago

Acthar Gel versus standard of care for adults with proteinuria in nephrotic syndrome due to focal segmental glomerulosclerosis: cost-per-response analysis from the US healthcare perspective Aim: Proteinuria poses a significant challenge in focal segmental glomerulosclerosis (FSGS), particularly when resistant to standard treatments. Acthar® Gel, a Food and Drug Administration (FDA)-appro...

📢New Research Article alert

"Acthar Gel versus standard of care for adults with proteinuria in nephrotic syndrome due to focal segmental glomerulosclerosis: cost-per-response analysis from the US healthcare perspective"

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#OpenAccess #JCER #KidneyDisease

Journal of Comparative Effectiveness Research

@journal-cer.bsky.social

2 months ago

Reshaping the cardiovascular continuum in the management of arterial and venous cardiovascular disease: a narrative review The prevalence of cardiovascular disease (CVaD) is expected to double in the next 25 years, fueled by increasing prevalence of diabetes mellitus, obesity and hypertension. Cardiovascular–kidney–m...

📢New article alert

New Review article on “Reshaping the cardiovascular continuum in the management of arterial and venous cardiovascular disease: a narrative review”.

🔗Read here: becarispublishing.com/doi/10.57264...

#OpenAccess #JCER #CardiovascularDisease #Prevention #IntegratedCare

Journal of Comparative Effectiveness Research

@journal-cer.bsky.social

2 months ago

The impact of socioeconomic crisis on cancer patient outcomes in Lebanon, 2018–2020 Aim: The goal of this study was to assess the impact of economic and social crisis on access to cancer care in Lebanon. Materials & methods: A cancer Drug Access Program in Lebanon was launched, c...

📢New article alert

New Research Article on “The impact of socioeconomic crisis on cancer patient outcomes in Lebanon, 2018–2020”.

🔗Read here: becarispublishing.com/doi/10.57264...

#OpenAccess #JCER #Oncology #GlobalHealth #HealthEquity #HealthPolicy

Journal of Comparative Effectiveness Research

@journal-cer.bsky.social

2 months ago

Comparison of deep prostate-specific antigen response in Black patients with metastatic castration-sensitive prostate cancer initiated on apalutamide or enzalutamide Aim: There is limited real-world evidence about prostate-specific antigen (PSA) response to androgen receptor pathway inhibitor treatment in Black patients with metastatic castration-sensitive prostat...

📢New article alert

New Short Report on "Comparison of deep prostate-specific antigen response in Black patients with metastatic castration-sensitive prostate cancer initiated on apalutamide or enzalutamide".

🔗Read here: becarispublishing.com/doi/10.57264...

#OpenAccess #JCER #ProstateCancer #RWE

Journal of Comparative Effectiveness Research

@journal-cer.bsky.social

2 months ago

📢New article alert

New Review article on "The importance and challenge of comparing stroke care, utilization and outcomes in Medicare Advantage and Fee-for-Service Medicare: a narrative review and vision for the future".

🔗Read here: becarispublishing.com/doi/10.57264...

#OpenAccess #JCER #Stroke

Journal of Comparative Effectiveness Research

@journal-cer.bsky.social

2 months ago

📢New article alert

New Meta-Analysis: "Effectiveness and safety of therapies for patients with opioid use disorder: a systematic review and network meta-analysis"

🔗Read here: becarispublishing.com/doi/10.57264...

#OpenAccess #JCER #OpioidUseDisorder #NetworkMetaAnalysis #PublicHealth

Journal of Comparative Effectiveness Research

@journal-cer.bsky.social

2 months ago

📢New article alert

New Meta-Analysis on "Population-adjusted network meta-analyses provide new insights into the efficacy of treatment alternatives for metastatic castration-sensitive prostate cancer".

🔗Read here: becarispublishing.com/doi/10.57264...

#OpenAccess #JCER #NMA #ProstateCancer

Journal of Comparative Effectiveness Research

@journal-cer.bsky.social

3 months ago

📢New article alert

“Long-term efficacy and safety of lorlatinib versus alectinib in anaplastic lymphoma kinase-positive advanced/metastatic non-small cell lung cancer: matching-adjusted indirect comparison”

🔗 becarispublishing.com/doi/10.57264...

#OpenAccess #JCER #NSCLC #MAIC #ITC #Oncology

Journal of Comparative Effectiveness Research

@journal-cer.bsky.social

3 months ago

Cost-effectiveness modeling of mortality risk reduction comparing two fixed-dose combination triple therapies in moderate-to-very severe chronic obstructive pulmonary disease Aim: Two fixed-dose combination triple therapies, budesonide/glycopyrronium/formoterol fumarate dihydrate (BGF) 320/14.4/10 μg and fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) 100/62....

📢New article alert

“Cost-effectiveness modeling of mortality risk reduction comparing two fixed-dose combination triple therapies in moderate-to-very severe chronic obstructive pulmonary disease”

🔗Read here: becarispublishing.com/doi/10.57264...

#OpenAccess #JCER #COPD #CostEffectiveness #HEOR

Journal of Comparative Effectiveness Research

@journal-cer.bsky.social

3 months ago

Acceptability of external control-arm use in nononcology health technology assessment submissions Aim: This study assessed the acceptability of external control-arm (ECA) use in nononcology health technology assessment (HTA) submissions in Europe. Materials & methods: We conducted a sequential...

📢New article alert

New Short Report on “Acceptability of external control-arm use in non-oncology health technology assessment submissions”

🔗Read here: becarispublishing.com/doi/10.57264...

#OpenAccess #JCER #HTA #RWE #ExternalControls #Methodology

Journal of Comparative Effectiveness Research

@journal-cer.bsky.social

3 months ago

📢New article alert

In two new Research Articles, researchers examine real-world patterns of care, utilization and outcomes in significant tricuspid regurgitation

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🔗 becarispublishing.com/doi/10.57264...

#OpenAccess #JCER #RWE #Cardiovascular #HEOR

Journal of Comparative Effectiveness Research

@journal-cer.bsky.social

3 months ago

Effectiveness of motor relearning program in sit-to-stand transfer and activities of daily living among chronic stroke patients – a prospective, multicenter, randomized controlled trial Aim: Stroke is a clinically defined syndrome characterized by an acute, focal neurological deficit due to vascular injury. Strokes can result in various disabilities, including sensory and motor abnor...

📢New article alert

“Effectiveness of motor relearning program in sit-to-stand transfer and activities of daily living among chronic stroke patients – a prospective, multicenter, randomized controlled trial”

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#OpenAccess #JCER #Stroke #ClinicalTrial

Journal of Comparative Effectiveness Research

@journal-cer.bsky.social

3 months ago

Impact of lymph node dissection on overall survival and cancer-specific survival in elderly patients with early-stage non-small cell lung cancer: a SEER database analysis Aim: The aim of the study is to understand the impact of lymph node dissection (LND) on overall survival (OS) and cancer-specific survival (CSS) in elderly patients with early-stage non-small cell lun...

📢New article alert

New Research Article on “Impact of lymph node dissection on overall survival and cancer-specific survival in elderly patients with early-stage non-small cell lung cancer: a SEER database analysis”.

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#OpenAccess #JCER #NSCLC #RWD

Journal of Comparative Effectiveness Research

@journal-cer.bsky.social

3 months ago

Simplifying fractional polynomials in Bayesian network meta-analysis via variable powers Aim: Fractional Polynomial (FP) models are widely used in survival analysis for health technology assessment and network meta-analysis (NMA). However, current implementations rely on a fixed set of pr...

📢New article alert

New Methodology on “Simplifying fractional polynomials in Bayesian network meta-analysis via variable powers”.

🔗Read here: becarispublishing.com/doi/10.57264...

#OpenAccess #JCER #HTA #NMA #CER #BayesianStatistics #HEOR

Journal of Comparative Effectiveness Research

@journal-cer.bsky.social

3 months ago

Sepiapterin as a treatment for people living with phenylketonuria: a plain language summary of the APHENITY trial What is this summary about? This plain language summary is based on an article about the APHENITY trial that was published in The Lancet journal in October 2024. The APHENITY trial was a phase 3 clini...

📢New article alert

New PLSP on Sepiapterin as a treatment for people living with phenylketonuria: a plain language summary of the APHENITY trial.

🔗Read here: becarispublishing.com/doi/10.57264...

#OpenAccess #JCER #PLSP #PKU #RareDisease #PlainLanguage

Journal of Comparative Effectiveness Research

@journal-cer.bsky.social

3 months ago

📢New article alert

New Research Article on “Health outcomes and costs in patients prescribed anticholinergic medications for overactive bladder”.

🔗Read here: becarispublishing.com/doi/10.57264...

#OpenAccess #JCER #OAB #PatientSafety #HEOR

Journal of Comparative Effectiveness Research

@journal-cer.bsky.social

3 months ago

Evaluating amyloid-beta as a surrogate endpoint in trials of anti-amyloid-beta drugs in Alzheimer’s disease: a Bayesian meta-analysis Aim: The use of amyloid-beta (Aβ) clearance to support regulatory approvals of drugs in Alzheimer’s disease (AD) remains controversial. We evaluate Aβ as a potential trial-level surrogate endpoint for...

📢New article alert

New Research Article on “Evaluating amyloid-beta as a surrogate endpoint in trials of anti-amyloid-beta drugs in Alzheimer’s disease: a Bayesian meta-analysis”.

🔗 becarispublishing.com/doi/10.57264...

#OpenAccess #JCER #AlzheimersDisease #MetaAnalysis #SurrogateEndpoints

Journal of Comparative Effectiveness Research

@journal-cer.bsky.social

3 months ago

Evaluating the feasibility of a network meta-analysis comparing treatment options in polycythemia vera Aim: Polycythemia vera (PV), a rare, chronic myeloproliferative neoplasm, that negatively impacts patient outcomes, and optimal therapy remains unclear due to a lack of head-to-head trials. A targeted...

📢New article alert

New Research Article on “Evaluating the feasibility of a network meta-analysis comparing treatment options in polycythemia vera”

🔗Read here: becarispublishing.com/doi/10.57264...

#OpenAccess #JCER #MetaAnalysis #ITC #RareDiseases

Journal of Comparative Effectiveness Research

@journal-cer.bsky.social

3 months ago

Iron deficiency treatment pathway in Italy: patients’ perceptions of diagnosis and treatment Aim: This 2023 online survey assessed the management of patients with iron deficiency anemia/iron deficiency without anemia (IDA/IDWA) in Italy. Materials & methods: The study used the patient’s p...

📢New article alert

New Research Article on “Iron deficiency treatment pathway in Italy: patients’ perceptions of diagnosis and treatment”.

🔗Read here: becarispublishing.com/doi/10.57264...

#OpenAccess #JCER #Anemia #PatientExperience #RWE

Journal of Comparative Effectiveness Research

@journal-cer.bsky.social

3 months ago

Comparison treatments for basal ganglia hemorrhage: minimally invasive puncture and drainage versus craniotomy versus conservative treatment Aim: The optimal management strategies for spontaneous intracerebral hemorrhage in the basal ganglia region are still controversial. The purpose of the present study is to evaluate the clinical benefi...

📢New article alert

New Research Article: "Comparison treatments for basal ganglia hemorrhage: minimally invasive puncture and drainage versus craniotomy versus conservative treatment".

🔗Read here: becarispublishing.com/doi/10.57264...

#OpenAccess #JCER #Stroke #Neurosurgery

Journal of Comparative Effectiveness Research

@journal-cer.bsky.social

4 months ago

Adherence, treatment utilization, clinical and economic outcomes of patients with sickle cell disease with recurrent vaso-occlusive crises treated with recently approved chronic therapies in the US Aim: To describe real-world adherence, treatment utilization, vaso-occlusive crises (VOC) and economic outcomes in patients with sickle cell disease (SCD) with recurrent VOC treated with L-glutamine, ...

📢New article alert

New Research Article: "Adherence, treatment utilization, clinical & economic outcomes of patients with sickle cell disease with recurrent vaso-occlusive crises treated with recently approved chronic therapies in the US"

🔗 becarispublishing.com/doi/10.57264...

#OpenAccess #JCER

Journal of Comparative Effectiveness Research

@journal-cer.bsky.social

4 months ago

Matching-adjusted indirect comparison of kidney function in patients with immunoglobulin A nephropathy treated with nefecon or sparsentan Aim: We compared the effects of nefecon, an oral targeted-release budesonide formulation, and sparsentan, an oral, dual endothelin-angiotensin receptor antagonist, on estimated glomerular filtration r...

📢New article alert

New research: “Matching-adjusted indirect comparison of kidney function in patients with immunoglobulin A nephropathy treated with nefecon or sparsentan”.

🔗 becarispublishing.com/doi/10.57264...

#OpenAccess #JCER #KidneyDisease #RWE #MAIC #HEOR #ComparativeEffectiveness

Journal of Comparative Effectiveness Research

@journal-cer.bsky.social

4 months ago

Association of liver biomarker values beyond current thresholds and negative clinical outcomes in primary biliary cholangitis: analysis of a real-world healthcare claims database Aim: To assess the predictive effect of threshold deviations for multiple liver biomarkers on negative clinical outcomes, including hepatic decompensation, liver transplantation, and death in patients...

📢New article alert

New Research Article on "Association of liver biomarker values beyond current thresholds and negative clinical outcomes in primary biliary cholangitis: analysis of a real-world healthcare claims database".

🔗Read here: becarispublishing.com/doi/10.57264...

#OpenAccess #JCER

Journal of Comparative Effectiveness Research

@journal-cer.bsky.social

4 months ago

Cost-effectiveness of PD-L1 testing to guide immunotherapy for patients with advanced non-small-cell lung cancer in China Aim: This study aims to assess the cost-effectiveness of three major programmed death-ligand 1 (PD-L1) immunohistochemistry (IHC) testing assays in guiding immunotherapy for patients with advanced non...

📢New article alert

New Research Article on “Cost-effectiveness of PD-L1 testing to guide immunotherapy for patients with advanced non-small-cell lung cancer in China”.

🔗 becarispublishing.com/doi/10.57264...

#OpenAccess #JCER #NSCLC #CostEffectiveness #Immunotherapy

Journal of Comparative Effectiveness Research

@journal-cer.bsky.social

4 months ago

📢New article alert

New Research article in JCER on "Considerations for emulations of randomized controlled trials using real-world data: learnings from an emulation of MONALEESA-2".

🔗Read here: becarispublishing.com/doi/10.57264...

#OpenAccess #JCER #RWD #RWE #TrialEmulation #BreastCancer

Journal of Comparative Effectiveness Research

@journal-cer.bsky.social

5 months ago

Real-world evidence of pimavanserin utilization among patients with Parkinson’s disease psychosis: a review of real-world data that augments data from randomized controlled trials Aim: Pimavanserin (PIM) is the only US FDA-approved atypical antipsychotics (AAPs) for the treatment for hallucinations and delusions associated with Parkinson’s disease psychosis (PDP). In addition t...

📢 New in JCER:
“Real-world evidence of pimavanserin utilization among patients with Parkinson’s disease psychosis: a review of real-world data that augments data from randomized controlled trials”

🔗 becarispublishing.com/doi/10.57264...

#OpenAccess #JCER #ParkinsonsDisease #RWE

Journal of Comparative Effectiveness Research

@journal-cer.bsky.social

5 months ago

📢 New in research in JCER: “Healthcare cost comparison between first-line ibrutinib and acalabrutinib in chronic lymphocytic leukemia patients in the Veterans Affairs”

🔗 becarispublishing.com/doi/10.57264...

#OpenAccess #JCER #CLL #HEOR #RWE