Differential efficacy of two small molecule PHLPP inhibitors to promote nucleus Pulposus cell health Pharmacological inhibition of PHLPP via NSC45586 promotes nucleus pulposus cell health. NSC45586 is a potential drug candidate in treating IVD degeneration.

📢 Check out the work of #ISSLS member Svenja Illien-Junger et al. in #JORSpine on PHLPP1’s role in IVD degeneration & small molecule inhibitors. Full study 👉 onlinelibrary.wiley.com/doi/10.1002/...

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Analysis of Key Differential Metabolites in Intervertebral Disc Degeneration Based on Untargeted Metabolomics The results showed that 2-methyl-1,3-cyclohexadiene, SM(d16_1_24_1(15Z)), SM(d17_1_24_1(15Z)), SM(d18_1_16_0), SM(d18_1_24_1(15Z)), stearoyl sphingomyelin, the methylcysteine, L-methionine, cis, cis-...

Analysis of Key Differential Metabolites in Intervertebral Disc Degeneration Based on Untargeted Metabolomics #JORSpine #MassSpec onlinelibrary.wiley.com/doi/10.1002/...