Morphology and microscopic images of the CBC in PBRs treating MWW. (a) The combined form of bacteria and algae; (b) bacterial and algal polymers.
#MicrobiologyMonday: Farming fish and shrimp produces large volumes of wastewater. How can we treat it sustainably? 🌊🦠Indigenous cyanobacteria–bacteria biofilms already adapted to mariculture effluent can help! #JournalSpectrum: asm.social/2Rn
Relative abundance of the dominant bacterial phyla and fungal class averaged across endophytic and epiphytic niches of plant parts (nectar, leaf, branch, trunk, coarse root, root tip) and soil in different seasons (autumn and spring) in rice growing fields of B. ceiba.
#MicrobiologyMonday: Bacteria and fungi living on and inside Bombax ceiba (a tropical tree) shift dramatically with the seasons and habitat. The findings, published in #JournalSpectrum, have implications for sustainable agriculture and conservation. asm.social/2Nv
Pathogenesis dynamics and transcriptomic changes during influenza infection in mice.
Cathepsin S (CTSS), a lysosomal protease, is a central driver of influenza-induced epithelial injury, acting downstream of viral replication and cytokine signaling to promote apoptosis, inflammation, and barrier disruption. Learn more in #JournalSpectrum: asm.social/2IH
Dr. D Corry, K Mauk et al have discovered unexpected factors that help #Calbicans settle and persist in the #gut.
#JournalSpectrum @bcmhouston.bsky.social #BCMDeptMedicine #MedicalIndustryToday www.medicalindustrytoday.com/article/8433...
(A) Inhibitory effect of strain J7 on 10 pathogenic fungi, a1: control; a2: co-cultivation; a3: filtrate-modified medium culture.
#MicrobiologyMonday: Species of Aspergillus show promise as biocontrol agents. For example, a newly identified strain inhibited growth of an array of plant pathogens in the lab, while also boosting disease resistance and plant growth. #JournalSpectrum: asm.social/2wJ
Temporal dynamics of plasmid carriage and virulence-associated features in white phenotype isolates.
Through genomic and phenotypic analyses—including measurements of exopolysaccharides and siderophores—researchers elucidate the adaptive evolution of classic K. pneumoniae transitioning to convergent K. pneumoniae within the host. #JournalSpectrum: asm.social/2wn
(A) Suppose there are n subjects sampled at k time points respectively, and each sample of subjects has m features. The different sizes of the circles represent different sizes of abundance. (B) This table is a pseudo-matrix composed of curves, each representing the change in abundance of a certain feature of a subject during the sampling time points. (C) A series of distance matrices, each representing the distance between each subject in a different feature dimension. (D) The final distance matrix between each subject.
To address challenges associated with longitudinal microbiome analyses, researchers developed longitudinal microbial data distance (LorDist), an innovative method to model temporal microbial dynamics with enhanced precision. Learn more in #JournalSpectrum: asm.social/2vM
Heterotrophic utilization of polysaccharides as shown with a fluorescently labeled polysaccharide (FLAPS).
Bacteria can be selfish..."Selfish" bacterial uptake of polysaccharides minimizes release of smaller sugars into the environment, ensuring cells get a return on their enzymatic invest. This #JournalSpectrum paper outlines how to identify selfish bacteria: asm.social/2vh
Transepithelial electrical resistance (TEER) development during meningococcal infection. (A) Baseline TEER with median of n = 24 (D1-D4) or n = 36 (D5-D7) uninfected epithelial at t = 0. (B) TEER of epithelial layers over time in uninfected (red) and infected (blue) conditions. Dotted lines represent the mean of triplicate measurements (D1–D4) or single measurements (D5–D7) of individual strains. Solid blue lines represent the mean of all infected conditions. TEER fold change after 24 h of infection stratified by infecting meningococcal strain (C) or epithelial cell donor (D). t = 24 dots represent mean of triplicate (D1–D4) or single (D5–D7) measurements. Performed statistical tests: Kruskal-Wallis test (A), permutation-based Friedman test (C, D), Dunn’s post hoc test with Benjamini-Hochberg multiple comparison correction (C, D). Dunn’s test P values are grouped by level of significance, where *, **, and *** indicate P values of less than 0.05, 0.01, and 0.001, respectively. UI, uninf
What determines if Neisseria meningitidis colonization progresses into invasion? A study #JournalSpectrum shows that the outcome of meningococcal infection of the epithelium is highly dependent on specific donor-strain interactions. Get the full story: asm.social/2uV
(A) The antibacterial effect of Citrocin against L. monocytogenes (a 0.15 mg/mL Citrocin; b 0.15 mg/mL Citrocin after treatment at 121°C; c equal amount of PBS solution). (B) MBC detected by agar plate method. (C) Effect of Citrocin on biofilm formation. (D) Effect of Citrocin on biofilm elimination.
Citrocin, an antimicrobial peptide widely used in animal feed, has strong anti-biofilm effects against the foodborne pathogen L. monocytogenes; the compound limits bacterial motility & suppresses biofilm-related amino acid metabolism. #JournalSpectrum: asm.social/2ty
Dermcidin promoted the inhibitory effect of platelets against MRSA
Researchers identified a previously unrecognized antimicrobial peptide produced by human platelets (dermcidin), which impedes proliferation of MRSA and promotes the antibacterial effect of platelets on the pathogen. Explore the study in #JournalSpectrum: asm.social/2rA
Morphology of methanogenic communities on the 5th, 15th, and 25th days of cultivation at 20,000× magnification.
The β-lactam antibiotic amoxicillin (AMX) enhances methanogenesis by selectively shaping microbial communities, improving biomethane yield by 3.89 times to and improving production efficiency. Learn more in #JournalSpectrum: asm.social/2oW
MTC of 16 metal-tolerant bacterial isolates. Sixteen isolates were grown on Luria-Bertani (LB) medium
#MicrobiologyMonday: Metal-tolerant soil bacteria have varied genomic features that help them adapt to different metal ions. Combining strains with complementary tolerances could boost metal accumulation for diverse uses. Learn more in #JournalSpectrum: asm.social/2oO
Surfactant from mouse and rat lungs protects human primary cells from S. aureus-mediated cytotoxicity.
Natural and commercially available lung surfactants minimize the cytolytic capacity of S. aureus supernatants against primary human cells, in part by reducing transcript abundance of virulence factors. Learn more in #JournalSpectrum: asm.social/2oC
Schematic diagram of HBV&HCV-MCDA-AuNPs-LFB assay′s principle
For the first time, researchers developed a nanoparticle-based biosensor integrated with multiple cross-displacement amplification for visual and rapid identification of hepatitis B virus and hepatitis C virus. Read the article in #JournalSpectrum: asm.social/2nD
A mode of morphological transformation cycle of MP UPEC. This mode includes the following three stages of MP UPEC invasion of the urine epithelium: UPEC initially adopts a rod-shaped form, adheres to epithelial cells, and penetrates them through fimbriae and other adhesins. It then replicates extensively within these cells, transitioning from a dispersed rod-shaped to a dense, clustered, spherical form known as IBCs. Once the host epithelial cells perish, numerous UPEC are released into the external environment in a filamentous form. These UPEC then revert to their original rod-shaped form, seeking new epithelia of the urinary tract to adhere to, thus completing a full cycle of morphological transformation, leading to a constant invasion of the urinary tract system. UPEC, uropathogenic Escherichia coli; IBC, intracellular bacterial community; MP, morphotype positive.
Bacteria that adhere to epithelial cells, form intracellular bacterial communities or transition to filamentous forms are morphotype-positive. Research in #JournalSpectrum shows that morphotype-positive UPEC strains harbor a more virulence genes. asm.social/2jZ
What can microbial genomic traits tell us about the impacts of land-use change? Check out our latest paper on Amazonian soil microbes at #JournalSpectrum: journals.asm.org/doi/10.1128/...
@jubgontijo.bsky.social @louberrios.bsky.social @mykophile.bsky.social @aucollege.bsky.social @asm.org
The graph showing the ability of growth of different mutant strains of V. cholerae in the presence of sublethal doses of (A) ampicillin, (B) imipenem, (C) aztreonam, and (D) vancomycin antibiotics. Unpaired t-test with Welch’s correction was used to determine statistical significance (P < 0.05), with significance calculated relative to the N16961 strain (P-values < 0.05 (*), <0.01 (**), P-values < 0.001 (***) and P-values < 0.0001 (****).
The alarmone (p)ppGpp and transcription factor DksA reduce the efficacy of ꞵ-lactam and other antibiotics by modulating availability of peptidoglycan and cell membrane-associated metabolites via a reduction in membrane permeability. #JournalSpectrum: asm.social/2j5
Colony variants observed at different harvest times compared to parental strains of the V. cholerae isolates. The colony morphologies of the LB negative control remain stable over the course of the experiment. The variants were labeled by combining the strain designation, stress conditions (X, oxidative stress; ID, iron depleted; HO, osmotic stress; IR, iron replete), and harvest time in days.
Using experimental evolution, scientists explored how the morphology of clinical & environmental isolates of Vibrio cholerae change in stressful conditions, like iron depletion and oxidative stress. Learn more in #JournalSpectrum: journals.asm.org/doi/10.1128/...
Fabrication scheme of biodegradable polymeric nanoemulsions incorporating carvacrol and eugenol.
Plant phytochemicals emulsified with a biodegradable nanosponge can kill hypoxia-induced dormant Mycobacterium abscessus & improve skin wound infection in mice, highlighting the therapeutic potential of phytochemical nanoemulsions: asm.social/2hz #JournalSpectrum
Relative abundance of ear canal bacteria in each subject.
The ABCC11 gene polymorphism determines earwax characteristics and regulates composition of the ear canal microbiota/its metabolic pathways. These insights could help elucidate the pathogenesis of ear diseases. Learn more in #JournalSpectrum: journals.asm.org/doi/10.1128/...
Profiling the human microbiome using MultiTax-human database.
The MultiTax-human database integrates data from multiple sources and uses advanced classification techniques to provide a a high-resolution reference tool specifically designed for human microbiome research. Learn more in
#JournalSpectrum: asm.social/2gD
WT GASAP53 triggers fibrin clot dissolution when enmeshed in fibrin clots in the presence of hPg. Fluorescently labeled fibrinogen was combined with thrombin to form fibrin clots, which entrapped GASAP53 cells prior to initiation of live imaging. (A) hPg is added to the solution after fibrin clots are formed. (B) hPg is pre-incubated with GAS for 5 min prior to fibrin clot formation.
The immune system creates fibrin clots to trap Group A Streptococcus (GAS) and prevent spread. For the first time, scientists show that GAS can delay their escape from fibrin clots to access deeper tissue and cause more invasive disease. #JournalSpectrum: asm.social/2gc
