Epigenetics Update - The histone H3 lysine 36 demethylase KDM2A/FBXL11 controls Polycomb-mediated gene repression and germ cell development in male mice go.nature.com/4lPspqq

#Epigenetics #KDM2A #GermCells #Polycomb
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High-resolution insights without cell sorting; epigenometech.com

Epigenetic modification increases skeletal muscle resilience to metabolic stress - Nature Metabolism

RESEARCH BRIEFING | Y Wang, H Xie, Q Liu, N Wang, S Zhang, H Yin, W Kong, CY Wang et al. (HUST, CN)

#KDM2A loss in #skeletal #muscle confers flexible protection against #metabolic stress

Kdm2a inhibition in skeletal muscle improves metabolic flexibility in obesity - Nature Metabolism Kdm2a demethylates H3K36me2 to mediate fast-to-slow-twitch myofiber transition and reshape skeletal muscle metabolic flexibility under metabolic stress conditions.

RESEARCH | Y Wang, H Xie, Q Liu, CY Wang et al. (HUST, CN)

#Kdm2a demethylates #H3K36me2 to mediate fast-to-slow-twitch #myofiber transition and reshape #SkeletalMuscle metabolic flexibility under #metabolic stress conditions