JAMA Network Open graphic details an RCT on genomic screening for familial hypercholesterolemia, showing population (94 men, 18 women), intervention (112 participants), and findings (LDL-C reduction). Immediate disclosure: 55, delayed: 57.

RCT: Opportunistic #GenomicScreening for familial hypercholesterolemia + telegenetic counseling did not substantially lower #LDL_C at 6 months vs delayed results; further research is needed for clinical implementation. ja.ma/4jH5rBy

Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9): The Multifaceted Biology, Diseases, and Pharmaceutical Interventions Summary of PCSK9 inhibitor mechanisms. PCSK9 inhibitors (PCSK9-i) primarily lower LDL-cholesterol (LDL-C) by blocking PCSK9-mediated degradation of hepatic LDL receptors (LDLR), enhancing LDL clearan....

#Review in #MedComm
Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9): The Multifaceted Biology, Diseases, and Pharmaceutical Interventions doi.org/10.1002/mco2...

#PCSK9 #LDL_C #IschemicStroke #Intervention #Strategies #PrecisionTherapy #therapeutics