Holo‑RBP4, the #retinol carrier protein, activates #LatentHIV1 #proviruses via pathways independent of #RetinoicAcid, acting in lymphoid tissues and emerging as a natural #latency‑reversing agent to target reservoirs and advance #HIVcure.

#OpenAccess #STTT: doi.org/10.1038/s413...

Researchers identify #retinol-bound holo-RBP4 as a potent natural activator of #LatentHIV1 that reactivates the #virus via NF-κB-driven signaling without retinoic acid, reversing latency even in cells from ART-treated individuals.

#FeaturedArticle in #STTT: doi.org/10.1038/s413...