#LoweSyndrome

Enhanced #Notch dependent gliogenesis and delayed physiological maturation underlie neurodevelopmental defects in #LoweSyndrome

By Y. Sharma, P. Raghu et al @ncbsbangalore.bsky.social

🗞️ doi.org/10.1038/s443...

Enhanced Notch dependent gliogenesis and delayed physiological maturation underlie neurodevelopmental defects in Lowe syndrome | EMBO Molecular Medicine imageimageLoss of OCRL leads to defective neuronal excitability in Lowe Syndrome patient iPSC-derived neurons and increased GFAP in mature forebrain cortical neural cultures and brain organoids. Singl...

📢 Publication alert !

#LoweSyndrome is a rare #genetic disorder affecting the eyes, kidneys & the brain.

Team @cbmncbs.bsky.social has the first ever insightful findings into the brain defects with a potential to redesign therapy.

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