On stage now is Alistair Dunham of the Wellcome Sanger Institute with a talk about the standardization and joint analysis of 2041 MAVEs.

#VariantEffect26
#MAVEs
#AtlasOfVariantEffectsAlliance

Next to the stage is Jun Yang of St. Jude Children's Research Hospital - ALSAC. His presentation details MAVE-informed protein language models for predicting pharmacokinetics variant function at scale.

#VariantEffect26
#MAVEs #ProteinLanguageModels
#AtlasOfVariantEffectsAlliance

Before we break for morning coffee, Lea Starita from the University of Washington takes the stage to talk about how novel calibration methods are driving resolution of variants of unknown significance (VUS).

#VariantEffect26
#MAVEs #VAMPseq #SGE #MPRAs
#AtlasOfVariantEffectsAlliance

Staying on the cardiology theme, we're now hearing from Andrew Glazer of the Vanderbilt University Medical Center. His talk details three multimedia assays of SCN5A variant function informing arrhythmia risk prediction.

#VariantEffect26
#MAVEs #cardiology
#AtlasOfVariantEffectsAlliance

Next to take the stage is Chai Ann (Andy) Ng, of the Victor Chang Cardiac Research Institute. His talk discusses the integration of MAVE and patch clamp data to improve classification and risk prediction in KCNH2-LQTS.

#VariantEffect26
#MAVEs #Cardiology
#AtlasOfVariantEffectsAlliance

Opening the second day of talks at MSS 2026 is Prof. Matthew Hurles of the Wellcome Sanger Institute. His talk, 'Scaling MAVEs: Is this the end of the beginning?' discusses progress in efforts to deliver MAVEs at scale.

#VariantEffect26
#MAVEs
#AtlasOfVariantEffectsAlliance

Opening today's final MSS 2026 session is Alex H. Wagner from the Nationwide Children's Hospital. His talk, 'From functional assays to computable knowledge', focuses on making MAVE data usable in variant interpretation.

#VariantEffect26
#MAVEs #PediatricCancer
#AtlasOfVariantEffectsAlliance

Happy to share that 𝚊𝚌𝚖𝚐𝚜𝚌𝚊𝚕𝚎𝚛 is now on CRAN! 🎉
This means long-term stability and easy installation with:
𝚒𝚗𝚜𝚝𝚊𝚕𝚕.𝚙𝚊𝚌𝚔𝚊𝚐𝚎𝚜('𝚊𝚌𝚖𝚐𝚜𝚌𝚊𝚕𝚎𝚛')

🗞️ doi.org/10.1093/bioi...

#rstats #acmg #varianteffect #MAVEs #VEPs #genomics

Bradley Zero, Automaticamore, Maves, Wass - Outdoor at Paradise Grapevine | Paradise Grapevine Winery | Tickets | SESH.sx Paradise Grapevine Winery in Canada is set to transform its serene vineyard into a vibrant hub of electronic music, drawing in enthusiasts for an underground ev

Bradley Zero, Automaticamore, Maves, Wass - Outdoor at Paradise Grapevine @ Paradise Grapevine Winery - 06 Sep feat. Bradley Zero, Automaticamore, Maves

#SESH #BradleyZero #Automaticamore #Maves

Multiplexed assays of variant effect for clinical variant interpretation - Nature Reviews Genetics Multiplexed assays of variant effect (MAVEs) are highly scalable experimental approaches used to generate functional data for genetic variants. In this Review, McEwen et al. discuss the advances in…

🧬Multiplexed Assays of Variant Effect (MAVEs) generate functional data for thousands of variants in a single experiment, accelerating VUS reclassification and improving patient care.
#MAVEs #Genomics

Explore the latest advances in MAVE technologies:
www.nature.com/articles/s41...

Moulin à vent à #Maves (#LoirEtCher) Moulin en bois de forme prismatique rectangulaire, sommé d'une toiture à double pente. Il est... Suite 👉 https://monumentum.fr/monument-historique/pa00098472/maves-moulin-a-vent

Moulin à vent à #Maves (#LoirEtCher) Moulin en bois de forme prismatique rectangulaire, sommé d'une toiture à double pente. Il est...
Suite 👉 monumentum.fr/monument-historique/pa00...