Before we break for morning coffee, Lea Starita from the University of Washington takes the stage to talk about how novel calibration methods are driving resolution of variants of unknown significance (VUS).

#VariantEffect26
#MAVEs #VAMPseq #SGE #MPRAs
#AtlasOfVariantEffectsAlliance

Multiplex, multimodal mapping of variant effects in secreted proteins bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

I am beyond thrilled to share this preprint with Nicholas Popp from Doug Fowler’s lab. I can’t wait to see where MultiSTEP goes next! 🧬🔬

Take a look here! ⤵️
www.biorxiv.org/content/10.1...

#deepmutationalscan #dms #vampseq #factorix #factor9 #hemophiliab