Enhorabuena al equipo que está por detrás de #METALoci ahora publicado en en Nature Structural & Molecular Biology. En particular en grupo de @dariloops.bsky.social del #CABD que comparte autoría senior con Marc A. Marti-Renom @crg.eu @cnag-eu.bsky.social y Blanche Capel @durham.ac.uk
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Using Hi-C and H3K27Ac data, #METALoci reconstructs the 3D enhancer hubs (or "metaloci") for each gene during sex determination.
For example, the testis-specific upregulation of Sox9 is associated with formation of a metaloci (in red) including its two known enhancers, TESCO & Enh13. (11/n)

#METALoci is based on spatial autocorrelation analysis, classically employed in geostatistics already since the 1950’s, to describe how a variable depends on space at a global and local scales. (8/n)