graphical abstract

New work from our group: a model of MHC-II antigen exchange on hour–day timescales shows that susceptibility to the exchange catalyst HLA-DM is proportional to the peptide–MHC-II off-rate.

Link to the publication:
www.sciencedirect.com/science/arti...

#AntigenPresentation #MHCII #Immunology

1️⃣ Immune privilege.
👋 The CNS “introduces itself” to promote immune tolerance while communicating with the periphery.
🎁 MHCII presents endogenous regulatory self-peptides (“guardians”) along the brain draining lymphatics.
#Immunology #MHCII (2/10)