Matrix Metalloproteinases in Neuropathic Pain and Migraine: Friends, Enemies, and Therapeutic Targets Matrix metalloproteinases (MMPs) constitute a family of zinc-dependent endopeptidases that mediate extracellular matrix turnover and associated processes, such as cell survival, growth, and differentiation. This paper discusses important functions ...

Matrix Metalloproteinases in Neuropathic Pain and Migraine: Friends, Enemies, and Therapeutic Targets #MMP2 #MMP9 #MECFS #LongCovid

pmc.ncbi.nlm.nih.gov/articles/PMC...

STAT3 Contributes to Intracranial Aneurysm Formation and Rupture by Modulating Inflammatory Response Intracranial aneurysm (IA) is a common type of refractory cerebrovascular diseases. Inflammatory responses have been reported to be associated with the pathogenesis of IA. We aimed to study the role o...

STAT3 Contributes to Intracranial Aneurysm Formation and Rupture by Modulating Inflammatory Response #MMP2 #MMP9 #MECFS #LongCovid

pmc.ncbi.nlm.nih.gov/articles/PMC...

Ebastine impairs metastatic spread in triple-negative breast cancer by targeting focal adhesion kinase We sought to investigate the utility of ebastine (EBA), a second-generation antihistamine with potent anti-metastatic properties, in the context of breast cancer stem cell (BCSC)-suppression in triple...

pmc.ncbi.nlm.nih.gov/articles/PMC...

"EBA administration significantly impeded BCSC-enriched tumor burden, angiogenesis and distant metastasis while reducing MMP-2/-9 levels in circulating blood in vivo." #MMP2 #MMP9

Ebastine impairs metastatic spread in triple-negative breast cancer by targeting focal adhesion kinase We sought to investigate the utility of ebastine (EBA), a second-generation antihistamine with potent anti-metastatic properties, in the context of breast cancer stem cell (BCSC)-suppression in triple...

Ebastine impairs metastatic spread in triple-negative breast cancer by targeting focal adhesion kinase #STAT3 #ERK1 #ERK2 #MMP2 #MMP9 #EZH2 #MECFS #LongCovid

pmc.ncbi.nlm.nih.gov/articles/PMC...

Inhibition of Stat3 signaling pathway by nifuroxazide improves antitumor immunity and impairs colorectal carcinoma metastasis - PubMed Colorectal carcinoma (CRC) is the one of the most common cancers with considerable metastatic potential, explaining the need for new drug candidates that inhibit tumor metastasis. The signal transduce...

pubmed.ncbi.nlm.nih.gov/28055016/

"In addition, nifuroxazide markedly impaired CRC cell migration and invasion by downregulating phosphorylated-Stat3Tyr705, and also impaired the expression of matrix metalloproteinases ( #MMP2 and #MMP9)."

Inhibition of Stat3 signaling pathway by nifuroxazide improves antitumor immunity and impairs colorectal carcinoma metastasis - PubMed Colorectal carcinoma (CRC) is the one of the most common cancers with considerable metastatic potential, explaining the need for new drug candidates that inhibit tumor metastasis. The signal transduce...

Inhibition of #Stat3 signaling pathway by nifuroxazide improves antitumor immunity and impairs colorectal carcinoma metastasis #ALDH1 #MMP2 #MMP9 #MECFS #LongCovid

pubmed.ncbi.nlm.nih.gov/28055016/

Executive summaries never over 2 pages, preferably 1. #heweb09 #MMP2

Objectives must be measurable, attainable, and have a time period. #heweb09 #mmp2