MUC4 Mutations Linked to Elevated Risk for Thrombosis in Patients With PNH A mouse model of lower limb deep vein thrombosis confirmed the thrombotic tendency in PNH mice, along with the fact that MUC4 deficiency further promoted the thrombotic phenotype of the mice.

The presence of #MUC4 genetic mutations significantly increases the risk for developing thromboses in individuals with paroxysmal nocturnal hemoglobinuria (#PNH).

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#RareDisease #ParoxysmalNocturalHemoglobinuria #MedSky