A Polygenic Score for #PerpheralArteryDisease #MajorAdverseLimbEvent

~69k
6 TIMI trials
2.6 y f/up
577 MALE (ALI CTLI Major amputation Peripheral revascularization)

Risk
⬆️15%➡️PAD prevalence
⬆️30%➡️MALE
⬆️27%➡️MI
⬆️10%➡️Stroke

More powerful in non-smokers

#EHJ 2025
academic.oup.com/eurheartj/ad...