Genetic modeling of ELP1-associated Sonic hedgehog medulloblastoma identifies MDM2 as a selective therapeutic target Elp1 heterozygous LOF mutations in Sonic hedgehog medulloblastoma (MB) elevate transformation risk in granule neuron precursors through stalled differentiation, DNA replication stress, genomic instabi...

🧠 Recently published in Cancer Cell: Genetic modeling of ELP1-associated Sonic hedgehog medulloblastoma identifies MDM2 as a selective therapeutic target. Read the full article: www.cell.com/cancer-cell/... #EANOessentials #NeuroOncology #MalignantBrainTumor #medulloblastoma #medsky

Availability and use of PET in patients with brain tumours – a European Organisation for Research and Treatment of Cancer - Brain Tumour Group (EORTC-BTG) survey - European Journal of Nuclear Medicine... Purpose Positron emission tomography (PET) is increasingly used in neuro-oncology. However, little is known about its application across European institutions and reasons for variable implementation. ...

🧠 A recent EORTC - European Organisation for Research and Treatment of Cancer study highlights the availability and use of amino acid PET in patients with brain tumors. 🔗 Read the full story: link.springer.com/article/10.1...
#EANOessentials #NeuroOncology #MalignantBrainTumor #PETimaging #medsky

Cellular hierarchies of embryonal tumors with multilayered rosettes are shaped by oncogenic microRNAs and receptor–ligand interactions - Nature Cancer Beck et al. conducted single-cell and spatial profiling of embryonal tumors with multilayered rosettes, finding that malignant cellular hierarchies are driven by developmental programs and specific me...

🧠 Recently published in Nature Cancer: Cellular hierarchies of embryonal tumors with multilayered rosettes are shaped by oncogenic microRNAs and receptor–ligand interactions Learn more: www.nature.com/articles/s43...

#EANOessentials #NeuroOncology #MalignantBrainTumor #PediatricBrainCancer #medsky

ROBIN: A unified nanopore-based assay integrating intraoperative methylome classification and next-day comprehensive profiling for ultra-rapid tumor diagnosis AbstractBackground. Advances in our technological capacity to interrogate CNS tumor biology have led to the ever increasing use of genomic sequencing in di

🧬 A new article on ultra-rapid tumor diagnosis is now available in Neuro-Oncology: "ROBIN: A unified nanopore-based assay integrating intraoperative methylome classification and next ..." 🔗 Full access: doi.org/10.1093/neuo...
#EANOessentials #NeuroOncology #MalignantBrainTumor #methylomics #medsky

Prospective, multicenter validation of a platform for rapid molecular profiling of central nervous system tumors - Nature Medicine Application of a nanopore sequencing workflow for real-time analysis of brain tumors results in molecular classification within a 30-minute intraoperative window, followed by comprehensive profiling w...

🧠 A recent publication in Nature Medicine covers the prospective, multicenter validation of a platform for rapid molecular profiling of central nervous system tumors.
🔗 Learn more: doi.org/10.1038/s415...
#MalignantBrainTumor #NeuroOncology #BrainTumors #EANOessentials

cIMPACT-NOW update 9: Recommendations on utilization of genome-wide DNA methylation profiling for central nervous system tumor diagnostics Abstract. Genome-wide DNA methylation signatures correlate with and distinguish central nervous system (CNS) tumor types. Since the publication of the init

A new open access article: cIMPACT-NOW update 9 – recommendations on genome-wide DNA methylation profiling for CNS tumor diagnostics – is now available in Neuro Oncology Advances 🔗 academic.oup.com/noa/article/... 🔓 #EANOessentials #NeuroOncology #MalignantBrainTumor