Presented at #EANO2025, now published in Cancer Research: MIF-Induced CD74+ Microglia and Macrophages Promote Progression of Brain Metastasis are Clinically Relevant Across Central Nervous System Disorders
Read more: aacrjournals.org/cancerres/ar...
#EANOessentials #NeuroOncology #OpenAccess

📚 Recently published in @cellpress.bsky.social – insights into #immunotherapy in #glioblastoma: Persistent T cell activation and cytotoxicity against glioblastoma following single oncolytic virus treatment in a clinical trial
Full article: www.sciencedirect.com/science/arti...
#EANOessentials

🧠 Recently published in Brain Pathology:
cIMPACT-NOW update 11: Proposal on adaptation of diagnostic criteria for IDH- and H3-wildtype diffuse high-grade gliomas and for posterior fossa ependymal tumors
Read full article: pubmed.ncbi.nlm.nih.gov/40887057/

#EANOessentials #NeuroOncology #OpenAccess

🧠 Now published in Neuro-Oncology: “The prognostic impact of CDKN2A/B hemizygous deletions in #meningioma.” This new study, led by Franziska M. Ippen, builds on preliminary results previously presented at #EANO in Glasgow.
🔗 Learn more: doi.org/10.1093/neuo...

#EANOessentials #NeuroOncology

🧠 Just published in Nature Genetics: "A microenvironment-determined risk continuum refines subtyping in meningioma and reveals determinants of machine learning–based tumor classification."
🔗 www.nature.com/articles/s41...

#EANOessentials #NeuroOncology #Meningioma #MachineLearning #OpenAccess

Recently published in @cp-immunity.bsky.social: Spatial immune profiling defines a subset of human gliomas with functional tertiary lymphoid structures. 👉 Full article:
www.cell.com/immunity/ful...

#NeuroOncology #Glioma #OpenAccess #EANOessentials

Associations of supramaximal resection with outcome in glioblastoma across age groups: A report of the RANO resect group AbstractAbstract. BackgroundThe oncological role of resection in elderly patients with glioblastoma remains controversial. We evaluated the value of resect

Presented at #EANO2025 and published in Neuro Oncology: Associations of supramaximal resection with outcome in glioblastoma across age groups: a report of the RANO resect group by Philipp Karschnia et al
👉 Learn more: doi.org/10.1093/neuo...

#RANO #glioblastoma #surgery #EANOessentials

Multimodality mapping of immunotherapy distribution as a predictive marker in glioma AbstractBackground. Scarce T cell infiltration, immunosuppressive tumor-associated macrophages and ineffective drug delivery drive glioma progression and l

First presented at #EANO2024, this work has now been published in Neuro-Oncology.
👉 academic.oup.com/neuro-oncolo...

#NeuroOncology #EANO #Glioma #ResearchHighlights #EANOessentials

@lukasbunse.bsky.social @venkataramanilab.bsky.social
@wickwolfgang.bsky.social @michael-platten.bsky.social

Molecularly matched targeted therapies plus radiotherapy in glioblastoma: the phase 1/2a N2M2 umbrella trial - Nature Medicine In a phase 1/2a umbrella trial in patients with glioblastoma matching targeted therapies according to tumor molecular profiling, temsirolimus plus radiotherapy improved PFS compared to standard of car...

🧠 The phase 1/2 N2M2 umbrella trial lead by former EANO president @wickwolfgang.bsky.social has just been published in Nature Medicine
🔗 www.nature.com/articles/s41...

#NeuroOncology #EANOessentials #BrainTumors #CancerResearch

Evolutionary trajectories of IDH-mutant astrocytoma identify molecular grading markers related to cell cycling - Nature Cancer Vallentgoed et al. integrate clinical and multiomic data from persons with matched initial and recurrent IDH-mutant astrocytomas to identify progression-associated mechanisms and report a DNA methylat...

🚨 New in Nature Cancer: “Evolutionary trajectories of IDH-mutant astrocytoma…” by Wies Vallentgoed et al. 🧠 Research supported by EANO Scholarships!
#CancerResearch #Glioma #NeuroOncology #EANOessentials
🔗 www.nature.com/articles/s43...
@nature.com

Nerve-to-cancer transfer of mitochondria during cancer metastasis - Nature A study reports the development of a method to trace intercellular transfer of mitochondria, and demonstrates that cancer cells that receive mitochondria from neurons have enhanced metastatic capabili...

👉 An article discussing nerve-to-cancer transfer of mitochondria during cancer metastasis is now available in @nature.com 🔗 www.nature.com/articles/s41... #CancerResearch #BrainMetastases #NeuroOncology #EANOessentials #Nature #medsky

Barcoded viral tracing identifies immunosuppressive astrocyte–glioma interactions - Nature Using viral barcode tracing to detect interactions between glioblastoma cells and non-malignant astrocytes in patient samples, investigators discovered a pathway that reduces tumour-specific immunity ...

A recent publication in @nature.com covers immunosuppressive astrocyte–glioma interactions identified through barcoded viral tracing.
🔗 www.nature.com/articles/s41...

#NeuroOncology #Glioma #CancerImmunology #BrainTumor #Nature #EANOessentials #medsky

Cholinergic neuronal activity promotes diffuse midline glioma growth through muscarinic signaling Midbrain cholinergic neuronal activity promotes the proliferation of both oligodendrocyte precursor cells and diffuse midline glioma (DMG) cells in a circuit-dependent manner, mediated by muscarinic M...

Recently published in @cellpress.bsky.social : A new study provides insights into cholinergic neuronal activity and diffuse midline glioma growth through muscarinic signaling.
🔗 Read full article: www.cell.com/cell/fulltex...

#NeuroOncology #Glioma #EANOessentials #medsky

Regulatory T cell depletion promotes myeloid cell activation and glioblastoma response to anti-PD1 and tumor-targeting antibodies (Immunity 58, 1236–1253.e1–e8; May 13, 2025)

💡 A recent study published in Cell Press Immunity examines the impact of regulatory T cell depletion on myeloid cell activation and glioblastoma response to anti-PD1 and tumor-targeting antibodies.
🔗 www.cell.com/immunity/ful...

#Glioma #NeuroOncology #Immunity #Tcells #EANOessentials #medsky

Stereotactic Radiosurgery in Patients With Small Cell Lung Cancer and 1-10 Brain Metastases: A Multi-Institutional, Phase II, Prospective Clinical Trial PURPOSEStereotactic radiation (SRS/SRT) as opposed to whole-brain radiation (WBRT) represents the standard of care for patients with a limited number of brain metastases given the relatively favorable...

A recent publication in Journal of Clinical Oncology covers stereotactic radiosurgery in small cell lung cancer patients with 1–10 brain metastases, from a multi-institutional phase II prospective trial.
🔗 ascopubs.org/doi/10.1200/...
#NeuroOncology #Glioma #BrainMetastases #EANOessentials #medsky

RANO seizure working group-Tumor Related Epilepsy Assessment Tool (RANO-TREAT) to assess seizure control for glioma treatment trials and clinical practice AbstractBackground. No standardized method exists for seizure assessment in glioma clinical trials. We describe the development and evaluation of RANO-TREA

🧠 A recent publication in Neuro-Oncology introduces the RANO-TREAT tool by the RANO Seizure Working Group. It supports seizure control assessment in glioma trials and clinical practice.
🔗 academic.oup.com/neuro-oncolo...

#NeuroOncology #Glioma #epilepsy #EANOessentials #medsky

Predicting therapeutic clinical trial enrollment for adult patients with low- and high-grade glioma using supervised machine learning Supervised machine learning models were designed and externally validated to predict glioma therapeutic clinical trial enrollment.

A new article addressing clinical trial enrollment of glioma patients using supervised machine learning is now available in Science Advances.
📖 Read the full article: www.science.org/doi/10.1126/...
#EANOessentials #NeuroOncology #Glioma #MachineLearning #medsky

Genetic modeling of ELP1-associated Sonic hedgehog medulloblastoma identifies MDM2 as a selective therapeutic target Elp1 heterozygous LOF mutations in Sonic hedgehog medulloblastoma (MB) elevate transformation risk in granule neuron precursors through stalled differentiation, DNA replication stress, genomic instabi...

🧠 Recently published in Cancer Cell: Genetic modeling of ELP1-associated Sonic hedgehog medulloblastoma identifies MDM2 as a selective therapeutic target. Read the full article: www.cell.com/cancer-cell/... #EANOessentials #NeuroOncology #MalignantBrainTumor #medulloblastoma #medsky

👉 Recently published in Clinical Cancer Research: A population-level real-world analysis and single-center validation of melanoma brain metastasis epidemiology following dual-agent immunotherapy 🔗 doi.org/10.1158/1078... #EANOessentials #NeuroOncology #BrainMetastases #brainMets #medsky

Availability and use of PET in patients with brain tumours – a European Organisation for Research and Treatment of Cancer - Brain Tumour Group (EORTC-BTG) survey - European Journal of Nuclear Medicine... Purpose Positron emission tomography (PET) is increasingly used in neuro-oncology. However, little is known about its application across European institutions and reasons for variable implementation. ...

🧠 A recent EORTC - European Organisation for Research and Treatment of Cancer study highlights the availability and use of amino acid PET in patients with brain tumors. 🔗 Read the full story: link.springer.com/article/10.1...
#EANOessentials #NeuroOncology #MalignantBrainTumor #PETimaging #medsky

Clinical, molecular and radiological predictors of prognosis in newly diagnosed astrocytoma, IDH-mutant, WHO grade 4 AbstractBackground. Astrocytoma, isocitrate dehydrogenase-mutant, WHO grade 4 (Astro4), is a new tumor type in the 2021 WHO classification of central nervo

Recently published in Neuro-Oncology: Clinical, molecular and radiological predictors of prognosis in newly diagnosed astrocytoma, IDH-mutant, WHO grade 4. 🔗 doi.org/10.1093/neuo...

#EANOessentials #NeuroOncology #glioma #medsky

Cellular hierarchies of embryonal tumors with multilayered rosettes are shaped by oncogenic microRNAs and receptor–ligand interactions - Nature Cancer Beck et al. conducted single-cell and spatial profiling of embryonal tumors with multilayered rosettes, finding that malignant cellular hierarchies are driven by developmental programs and specific me...

🧠 Recently published in Nature Cancer: Cellular hierarchies of embryonal tumors with multilayered rosettes are shaped by oncogenic microRNAs and receptor–ligand interactions Learn more: www.nature.com/articles/s43...

#EANOessentials #NeuroOncology #MalignantBrainTumor #PediatricBrainCancer #medsky

ROBIN: A unified nanopore-based assay integrating intraoperative methylome classification and next-day comprehensive profiling for ultra-rapid tumor diagnosis AbstractBackground. Advances in our technological capacity to interrogate CNS tumor biology have led to the ever increasing use of genomic sequencing in di

🧬 A new article on ultra-rapid tumor diagnosis is now available in Neuro-Oncology: "ROBIN: A unified nanopore-based assay integrating intraoperative methylome classification and next ..." 🔗 Full access: doi.org/10.1093/neuo...
#EANOessentials #NeuroOncology #MalignantBrainTumor #methylomics #medsky

Glioblastoma-instructed astrocytes suppress tumour-specific T cell immunity - Nature A population of TRAIL-positive astrocytes in glioblastoma contributes to an immunosuppressive tumour microenvironment and this mechanism can be targeted with an engineered oncolytic virus to improve o...

🧠 A recent article on glioblastoma-instructed astrocytes suppressing tumour-specific T cell immunity is now available in @nature.com. 📖 Full article: www.nature.com/articles/s41...
#EANOessentials #NeuroOncology #Glioma #ImmunoOncology

Dissecting the immune landscape in pediatric high-grade glioma reveals cell state changes under therapeutic pressure LaBelle et al. show immune microenvironment changes following chemo-/radiotherapy and immune checkpoint blockade therapy via single-cell RNA-seq of matched tumor, T cells, and myeloid cells in pediatr...

🧠 Recently published in @cellpress.bsky.social: Dissecting the immune landscape in pediatric high-grade glioma reveals cell state changes under therapeutic pressure: Cell Reports Medicine. Learn more: www.cell.com/cell-reports... #EANOessentials #Glioma #ImmunoOncology #NeuroOncology

Molecular signatures define BAP1-altered meningioma as a distinct CNS tumor with deregulation of Polycomb repressive complex target genes AbstractBackground. Meningiomas are the most common primary intracranial neoplasms, with highly variable patient outcomes. While most meningiomas are benig

🧠 Recently published in Neuro-Oncology: Molecular signatures define BAP1-altered meningioma as a distinct CNS tumor with deregulation of Polycomb repressive complex target genes 🔗 doi.org/10.1093/neuo... #EANOessentials #NeuroOncology #Meningioma #CNS

The multilayered transcriptional architecture of glioblastoma ecosystems - Nature Genetics Integrated single-cell transcriptomic and genetic characterization of 121 adult glioblastomas identifies heterogeneity at cell type, cell state and baseline expression program levels associated with s...

🧠 A new article on the multilayered transcriptional architecture of glioblastoma ecosystems is now available in @nature.com. 🔗 www.nature.com/articles/s41...
#EANOessentials #NeuroOncology #glioma

Charting the Single-Cell and Spatial Landscape of IDH-Wildtype Glioblastoma with GBmap AbstractBackground. Glioblastoma (GB), particularly IDH-wildtype, is the most aggressive brain malignancy with a dismal prognosis. Despite advances in mole

Recently published in Neuro-Oncology: Charting the Single-Cell and Spatial Landscape of IDH-Wildtype Glioblastoma with GBmap. Read full article 👉 doi.org/10.1093/neuo... #EANOessentials #Neuro-Oncology #glioma #glioblastoma

Interferon-γ orchestrates leptomeningeal anti-tumour response - Nature Independent of antigen presentation, migratory CCR7+ dendritic cells orchestrate the influx, proliferation and cytotoxic action of natural killer cells to control cancer cell growth in the leptomening...

🧠 An article discussing the molecular interactions between metastases and immune cells within the leptomeninges is now available in @nature.com.
🔗 www.nature.com/articles/s41...
#EANOessentials #glioblastoma #NeuroOncology #leptomeningeal #metastases

Single-cell and spatial genomic landscape of non-small cell lung cancer brain metastases Nature Medicine - Multi-omic single-cell and spatial analyses of lung cancer brain metastases from multiple cohorts identify high levels of chromosomal instability and a neural-like profile in...

This research examines the single-cell and spatial genomic landscape of non-small cell lung cancer (#NSCLC) brain metastases. 🔗 Read the full article in Nature Medicine 👉 rdcu.be/eh8y7 #EANOessentials #NeuroOncology #BrainMetastases #btsm