Deciphering the Role of Cancer Stem Cells in Breast Cancer Brain Colonization Using a Novel Patient‐Derived Model This study shows that stem-like cells isolated from breast cancer brain metastases drive the spread and growth of tumors in the brain. Among them, a highly adhesive subgroup initiates metastasis and ...

Proud to share my last first-author paper.

We report a new clinically relevant model of #breastcancer #brainmetastases and #cancerstemcells as key metastases drivers due to their adaptive interaction with brain cells and vasculature.

Thanks to Giuliana Pelicci’s lab (IEO, Milan) and co-authors.

🔬 Prof. Leonie Young is a leading investigator whose research uncovers the molecular networks driving therapy resistance & metastatic progression in #BreastCancer. Her lab focuses on SRC‑mediated resistance pathways & mechanisms that shape tumor adaptation in #BrainMetastases.

🔬 Prof. Leonie Young is a leading investigator whose research uncovers the molecular networks driving therapy resistance & metastatic progression in #BreastCancer. Her lab focuses on SRC‑mediated resistance pathways & mechanisms that shape tumor adaptation in #BrainMetastases.

🔬 Prof. Leonie Young is a leading investigator whose research uncovers the molecular networks driving therapy resistance & metastatic progression in #BreastCancer. Her lab focuses on SRC‑mediated resistance pathways & the mechanisms that shape tumor adaptation in #BrainMetastases.

Incidence, Risk Factors, and Prognosis of Patients with Hepatocellular Carcinoma and Brain Metastases

Scientists show #BrainMetastases in #HepatocellularCarcinoma have age‑related incidence & risk factors, suggesting improved survival warrants selective #BrainScreening in patients with lung or bone metastases for earlier detection and better counseling.
Read: doi.org/10.1007/s115...

Systemic HER3 ligand-mimicking nanobioparticles enter the brain and reduce intracranial tumour growth - Nature Nanotechnology Delivering therapeutics to the brain is challenging because of the hard-to-cross blood–brain barrier. Here, the authors show that HER3, which is expressed on the surface of many metastatic tumours,…

Research : doi.org/10.1038/s415...
@springernature.com

#bloodbrainbarrier #brainmetastases #braintumours #cancerdrugdelivery #her3receptor #nanomedicine

The clinical benefit of adding radiotherapy to ipilimumab in patients with melanoma brain metastasis: a systematic review and meta-analysis - Clinical & Experimental Metastasis Combining radiotherapy (RT) with Ipilimumab, a CTLA-4 inhibitor, holds promise in treating metastatic brain melanoma (MBM). Despite promising preclinical evidence, clinical studies evaluating their co...

Adding #radiotherapy (RT) to ipilimumab improves survival and disease control in #melanoma brain metastases, according to a new meta-analysis. #BrainMetastases #Immunotherapy #MetaAnalysis #Oncology link.springer.com/article/10.1...

STAT3 expression in brain metastases from breast cancer is correlated with molecular subtype and impacts clinical outcome - PubMed This study indicates that STAT3 expression prevails in reactive astrocytes surrounding triple-negative BrM in comparison to HER2-positive and luminal BrM, and these findings mirror those observed in…

High pSTAT3 in reactive astrocytes is linked to higher intracranial recurrence and shorter PFS in triple-negative #BreastCancer #BrainMetastases. STAT3 emerges as a potential prognostic biomarker and therapeutic target.

📖 Read the full article: pubmed.ncbi.nlm.nih.gov/40795951/

U01.20.022 Brain Metastases Study this flashcard to identify the most common primary tumors that metastasize to the brain, their typical imaging findings, and clinical relevance for USMLE Step 1.

Remember lung, breast, and melanoma as top causes of brain mets. #BrainMetastases #Oncology #Neurology #USMLE #MedicalEducation #Pathology

New therapy for active brain metastases successfully tested Read up on the study!

Promising results in patients with active #brainmetastases of various #tumour types. ☑️

A study led by #MedUniVienna shows that patritumab deruxtecan is effective in patients with #lungcancer & #breastcancer.

Details! ⬇️

📰 @thelancetoncol.bsky.social​

This research describes the age-related incidence and risk factors of #BrainMetastases in #HepatocellularCarcinoma patients with initial #Lung or #BoneMetastases, urging a reevaluation of screening and prognostic strategies for #HCC. #medsky
Read:
link.springer.com/article/10.1...

How do #metastases survive (and thrive!) in the #brain microenvironment?

In our review, now online @cp-neuron.bsky.social, we discuss the recent findings on #cancerneuroscience of #brainmetastases:
Learn all about how #cancer cells adapt to, and communicate with, this unique environment 🧠

🧠 New research reveals why #Immunotherapy often fails in symptomatic #BrainMetastases: some astrocytes block T-cell activity. By combining treatments, this local immunosuppression is no longer observed. A promising step towards personalized treatment! bit.ly/3IvfqLw

Nerve-to-cancer transfer of mitochondria during cancer metastasis - Nature A study reports the development of a method to trace intercellular transfer of mitochondria, and demonstrates that cancer cells that receive mitochondria from neurons have enhanced metastatic capabili...

👉 An article discussing nerve-to-cancer transfer of mitochondria during cancer metastasis is now available in @nature.com 🔗 www.nature.com/articles/s41... #CancerResearch #BrainMetastases #NeuroOncology #EANOessentials #Nature #medsky

Stereotactic Radiosurgery in Patients With Small Cell Lung Cancer and 1-10 Brain Metastases: A Multi-Institutional, Phase II, Prospective Clinical Trial PURPOSEStereotactic radiation (SRS/SRT) as opposed to whole-brain radiation (WBRT) represents the standard of care for patients with a limited number of brain metastases given the relatively favorable...

A recent publication in Journal of Clinical Oncology covers stereotactic radiosurgery in small cell lung cancer patients with 1–10 brain metastases, from a multi-institutional phase II prospective trial.
🔗 ascopubs.org/doi/10.1200/...
#NeuroOncology #Glioma #BrainMetastases #EANOessentials #medsky

💡Explore the latest breakthroughs in #CNS #radiationoncology as presented at #ESTRO25 — from simulation-free planning and LET-guided dose sculpting to #adaptiveRT and next-gen imaging biomarkers.
👉 bit.ly/450oWxZLink
#CNSOncology #Radonc #NeuroOncology #BrainMetastases

Protein helps lung cancer reach the brain in mice Researchers from Canada have discovered that a protein long connected to Alzheimer’s disease helps lung cancer cells in mice spread to the brain.

🧠 40% of patients with non-small cell #LungCancer suffer #BrainMetastases, and there are few therapies.
🔬 Researchers from McMaster University found that a protein linked to #AlzheimersDisease helps cancer spread to the brain in #mice.
🔗 eara.eu/post/protein...

#CancerResearch #DrugRepurposing

👉 Recently published in Clinical Cancer Research: A population-level real-world analysis and single-center validation of melanoma brain metastasis epidemiology following dual-agent immunotherapy 🔗 doi.org/10.1158/1078... #EANOessentials #NeuroOncology #BrainMetastases #brainMets #medsky

Presurgical Radiation Therapy May Offer Alternative Approach to Treating Brain Metastases Studies have suggested that pre-surgical SRT may be comparable to standard post-surgical SRT in patients with resectable brain metastases.

Presurgical Radiation Therapy May Offer Alternative Approach to Treating Brain Metastases
@mdanderson.bsky.social #BrainMetastases
www.onclive.com/view/presurg...

#BrainMetastases (BM) from #PancreaticCancer are rare. However, in 41% of cases, BM was the first sign of spread. Early neuroimaging in high-risk patients may enable earlier diagnosis and improve outcomes.
#Oncology #PrecisionOncology #ClinicalOncology #NeuroOncology #MetastaticCancer

Nivolumab/Relatlimab Elicit IC Activity in Anti–PD-L1–Refractory Melanoma Brain Mets The combination elicited a clinical benefit rate of 63.0% and an overall response rate of 22.2% in anti–PD-L1–refractory melanoma with melanoma brain metastases.

Nivolumab + relatlimab show promising intracranial activity in melanoma brain metastases! A beacon of hope for resistant cases and a call for more research!
#Melanoma #BrainMetastases #Immunotherapy #Nivolumab #Relatlimab #CheckpointInhibitors #TCSC #Oncology

www.cancernetwork.com/view/nivolum...

Featured today by @MSKLibrary: Multi-institutional atlas of brain metastases informs spatial modeling for precision imaging and personalized therapy dx.doi.org/10.1038/s414...

#MultiInstitutionalResearch #BrainMetastases #PrecisionImaging #PersonalizedTherapy #NeuroOncology #CancerResearch

#Sotorasib Is Not Effective in a #KRAS-Mutated Patient With #BrainMetastases From #LungAdenocarcinoma due to Multiple Gene Co-Mutations
onlinelibrary.wiley.com/doi/10.1002/...

Brain metastases Nature Reviews Disease Primers - An estimated 20% of all patients with cancer will develop brain metastases, with the majority of brain metastases occurring in those with lung and breast cancer and...

#Medsky🧪 #immunosky #oncosky #neurosky Up to 20 % of metastatic 🧠 tumors arise from primary BC www.nature.com/articles/s41... While primary #breastcancer is curable if caught early, metastatic tumors have significantly poorer survival rates. #Brainmetastases,

🌼 Our May Issue is now online 💐

📣 Don't miss the new Commentaries and EACR Viewpoint

🔓https://buff.ly/p3e9Zcr

#CancerResearch #TME #ExtracellularVesicles #BrainMetastases #Microglia #Melanoma

Single-cell and spatial genomic landscape of non-small cell lung cancer brain metastases Nature Medicine - Multi-omic single-cell and spatial analyses of lung cancer brain metastases from multiple cohorts identify high levels of chromosomal instability and a neural-like profile in...

This research examines the single-cell and spatial genomic landscape of non-small cell lung cancer (#NSCLC) brain metastases. 🔗 Read the full article in Nature Medicine 👉 rdcu.be/eh8y7 #EANOessentials #NeuroOncology #BrainMetastases #btsm

🎥 New on #OncologyBytes (IUCS 2024)
A rare prostate cancer case: Brain mets despite undetectable PSA.
Dr. Luciano Stumbo breaks it down — and why MRI matters.
📺 Watch: youtu.be/nFg2XbgkzrQ
🌐 More at: oncoassist.com

#IUCS2024 #ProstateCancer #BrainMetastases #Oncoassist #CancerCare #Oncoalert

🔬🧪 Using single-cell & bulk RNA sequencing, integrated with spatial analyses, we built a vascular and immune #atlas of brain tumors

🧠 GBMs have restricted immune infiltration, while BrMs have a more permeable vasculature and interact extensively with immune cells

#Glioblastoma #BrainMetastases

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Association Between Human Epidermal Growth Factor Receptor 2-Low Status and Time to Development of Brain Metastases Among Patients With Breast Cancer: A Retrospective Cohort Study | JCO Precision Onco... PURPOSEHuman epidermal growth factor receptor 2 (HER2)-low is a newly defined subgroup of HER2-negative breast cancer. It is unknown whether HER2-low status is associated with brain metastases (BrM) d...

En pacientes con cáncer de mama HR+, el HER2 bajo se asocia con un tiempo más corto entre el cáncer de mama primario y la metástasis cerebral, independientemente del estado del HR #HER2 #breastcancer #brainmetastases ascopubs.org/doi/full/10....

Recently published in @cellpress.bsky.social: Microglial reprogramming enhances antitumor immunity and immunotherapy response in melanoma brain metastases 👉 bit.ly/3XmWyD8
#EANOessentials #BrainMetastases #NeuroOncology