#CatSky😸 #EvoDevo

A deletion at the X-linked ARHGAP36 gene locus is associated with the orange coloration of tortoiseshell & calico cats

ARHGAP36
#XChromosomeInactivation
➖corr. #Melanogenesis

@currentbiology.bsky.social 2025
www.cell.com/current-biol...

😸credit
www.newsweek.com/rare-unicorn...

Read Yu et al's paper:
The #Pigmentation of Blue Light Is Mediated by Both #Melanogenesis Activation and Autophagy Inhibition through OPN3–TRPV1 doi.org/10.1016/j.ji...
and Kohli and Lim's Commentary:
Blue Light–Induced Pigmentation doi.org/10.1016/j.ji...
#dermatology #dermsky #dermatologists

How does the redhead MC1R mutation cause red hair? New @plosbiology.bsky.social study shows that the R151C & R160W mutations affect binding of MC1R to the #BBSome in the primary cilium of #melanocytes after UV exposure, impacting the downstream stimulation of #melanogenesis - plos.io/4eZYebx