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New research from #JRSocInterface: Melanin pigments protect nucleic acid integrity royalsocietypublishing.org/rsif/article... | #Biochemistry #Melanocytes #Melanoma

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MC1R and IRF4 gene variants associate with p16INK4a positive epidermal cells. Basal cell carcinoma (BCC) cases in sun-protected skin are estimated to be between 20-33% of total cases, highlighting a non-ultraviolet radiation (UVR) influence on BCC incidence. Here, we tested the...

Senescent #melanocytes in aging skin may contribute to development of basal cell carcinoma #BCC ow.ly/iCRm50Wiova #medderm #dermsky

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How does the redhead MC1R mutation cause red hair? New @plosbiology.bsky.social study shows that the R151C & R160W mutations affect binding of MC1R to the #BBSome in the primary cilium of #melanocytes after UV exposure, impacting the downstream stimulation of #melanogenesis - plos.io/4eZYebx

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