#HighIntensityIntervalTraining alleviates #heartfailure by boosting skeletal muscle–derived #Metrnl, which activates AMPK-HDAC4 signaling in #cardiomyocytes to enhance GLUT4 expression, aerobic glucose metabolism and mitochondrial function.

#OpenAccess: doi.org/10.1016/j.ge...

METRNL represses beta-to-alpha cell trans-differentiation to maintain beta cell function under diabetic metabolic stress in mice - Diabetologia Aims/hypothesis In type 2 diabetes mellitus, beta cell failure is associated with pancreatic beta cell dedifferentiation and trans-differentiation into other types of islet cells. However, the mechani...

METRNL maintains beta cell function and identity by preventing beta-to-alpha cell trans-differentiation under metabolic stress #Diabetes #Islets #DiabetesResearch #METRNL link.springer.com/article/10.1...

Elevated meteorin-like protein from high-intensity interval training improves heart function via AMPK/HDAC4 pathway

This study reveals that #HighIntensityIntervalTraining (#HIIT) increases skeletal muscle #Metrnl production, which acts on #HeartFailure hearts to alleviate their functional defects by increasing aerobic glucose metabolism through AMPK-HDAC4 signaling. #medsky

#OpenAccess:https://buff.ly/Ncir3SF