#MicrovascularAging 🐴Tendon

Young 2~5 y/o
Aged 18~22 y/o
Superficial digital flexor tendon

⏬μCT microvascular (φ>=37 μm) density, φ
⏫VWF+ microvessels
⏫PDGFRβ+ pericytes
⏬Des+/Myh11+ mural cells

5 mm cubes for 3D immunostaining

#AgingCell 2025
onlinelibrary.wiley.com/doi/10.1111/...

#MicrovascularAging
An opulent study on CNS #MuralCell Notch3🤠

Aging👤->⏬Notch3 in Arterial/Arteriolar #SmoothMuscleCell (Likely EC as well?)

Notch3-/-🐭->
Loss of🧠SMC contractility & coverage
Cerebral arterial tortuosity, microaneurysm

Arispe lab #JCI 2023
www.jci.org/articles/vie...