Epitranscriptomics #PhaseSeparation
m6A-modified #EnhancerRNA & YTHDC1-BRD4 assemble transcriptional condensate
MINT-seq detects >3-fold more m6A peaks than MeRIP-seq
Stringtie annotate eRNAs & promoter upstream antisense RNAs, 24% & 48% are m6A+ (MCF7)
#MolCell 2021
www.cell.com/molecular-ce...
Very excited to share our latest work in #MolCell showing NPM1 stabilizing the association of nucleolus associated domains (NADs) and recruiting G9a to establish their repressive chromatin states. www.sciencedirect.com/science/arti...
#Centromere #Aging
"Centromeric transcription & CENP-A/C is epigenetically downregulated in Aging"
H3K9me3⏫ H3K4me2⏬on centromere/pericentromeric DNA
Rescued by p53 siRNA + KDM1A inhibitor➡️⏫genomic stability & mitotic fidelity of aged fibroblast
#MolCell 2025
www.sciencedirect.com/science/arti...
