🔥New SARS-CoV-2 Inhibitor
A study identifies #C10, a potent #NSP14 inhibitor via structure-guided #virtualscreening. #DSF/#SPR confirm nanomolar, SAM-competitive binding; FP/FRET shows high selectivity. Docking, MD, mutagenesis & HDX-MS complete validation.
medchemexpress.com/spr-service.html

Targeting #Nsp14 as a promising pan-coronavirus strategy. 🧪

Discovery of highly potent SARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5′-carboxamides The emergence of SARS-CoV-2, the causative agent of COVID-19, has highlighted the need for advanced antiviral strategies. Targeting the coronaviral methyltransferase nsp14, which is essential for RNA ...

#research #SARSCoV2 #nsp14

Discovery of highly potent SARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5′-carboxamides (Nencka) - RSC? doi.org/10.1039/D4MD...

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